Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions
文献类型：期刊论文
| 作者 | Wang, Yiling2; Li, Dongli2; Lin, Huiqiong1; Jiang, Sen1; Han, Lei1; Hou, Shuli1; Lin, Shuying1; Cheng, Zhefeng1; Bian, Wangqing1; Zhang, Xinxin3
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| 刊名 | FOOD SCIENCE & NUTRITION
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| 出版日期 | 2020-05-28 |
| 页码 | 14 |
| ISSN号 | 2048-7177 |
| 关键词 | anti-inflammatory bioavailability pharmacokinetics phloretin self-nanoemulsions solubility |
| DOI | 10.1002/fsn3.1637 |
| 通讯作者 | He, Yan(lzbzm@163.com) ; Zhang, Kun(Zhangtinghua_js@163.com) |
| 英文摘要 | Phloretin (Ph) is a natural active ingredient with wide biological properties. However, its poor water-solubility and low oral bioavailability limit the application significantly in functional food and drug. This study was to explore the mixed polymer Pluronic (R) F127 and P123 modified the different triglycerides (LCT, MCT, SCT) in self-nanoemulsions (SNEs) for enhancing the oral bioavailability and bioefficacy of Ph. The SNEs were characterized in terms of physical property study, lipolysis study, pharmacokinetic study, and anti-inflammatory effect. The water-solubility of LCT-Ph-SNE increased 3000-fold compared with Ph solution. Pharmacokinetic study of SNEs and other carriers (HP-beta-CD, PVP) results indicated that LCT-Ph-SNE was 7.9-fold more bioavailable compared with unformulated Ph. The anti-inflammatory activity of LCT-Ph-SNE in vivo represented a 6.8-fold enhancement compared with unformulated Ph. This novel SNE formulation may also be used for other poorly soluble ingredients with high loading capacity, which made a significant impact on functional food and drug. |
| WOS关键词 | DRUG-DELIVERY SYSTEM ; ANTIOXIDANT ; FORMULATION ; INHIBITION ; DIGESTION |
| 资助项目 | Department of Science and Technology of Jiangmen[2016350100170008351] ; Jiangmen Program for Innovative Research Team[2018630100180019806] ; Department of Education of Guangdong Province[2016KCXTD005] ; Department of Education of Guangdong Province[2017KSYS010] |
| WOS研究方向 | Food Science & Technology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000535881700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280048]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | He, Yan; Zhang, Kun |
| 作者单位 | 1.Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China 2.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yiling,Li, Dongli,Lin, Huiqiong,et al. Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions[J]. FOOD SCIENCE & NUTRITION,2020:14. |
| APA | Wang, Yiling.,Li, Dongli.,Lin, Huiqiong.,Jiang, Sen.,Han, Lei.,...&Zhang, Kun.(2020).Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions.FOOD SCIENCE & NUTRITION,14. |
| MLA | Wang, Yiling,et al."Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions".FOOD SCIENCE & NUTRITION (2020):14. |
入库方式： OAI收割
来源：上海药物研究所
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