中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Update of P2Y receptor pharmacology: IUPHAR Review 27

文献类型:期刊论文

作者Jacobson, Kenneth A.4; Delicado, Esmerilda G.5; Gachet, Christian6; Kennedy, Charles7; von Kuegelgen, Ivar1; Li, Beibei8; Miras-Portugal, M. Teresa5; Novak, Ivana9; Schoeneberg, Torsten2; Perez-Sen, Raquel5
刊名BRITISH JOURNAL OF PHARMACOLOGY
出版日期2020-06-01
卷号177期号:11页码:2413-2433
ISSN号0007-1188
DOI10.1111/bph.1500510.1111/bph.15005
通讯作者Jacobson, Kenneth A.(kennethj@niddk.nih.gov)
英文摘要Eight G protein-coupled P2Y receptor subtypes respond to extracellular adenine and uracil mononucleotides and dinucleotides. P2Y receptors belong to the delta group of rhodopsin-like GPCRs and contain two structurally distinct subfamilies: P2Y(1), P2Y(2), P2Y(4), P2Y(6), and P2Y(11) (principally G(q) protein-coupled P2Y(1)-like) and P2Y(12-14) (principally G(i) protein-coupled P2Y(12)-like) receptors. Brain P2Y receptors occur in neurons, glial cells, and vasculature. Endothelial P2Y(1), P2Y(2), P2Y(4), and P2Y(6) receptors induce vasodilation, while smooth muscle P2Y(2), P2Y(4), and P2Y(6) receptor activation leads to vasoconstriction. Pancreatic P2Y(1) and P2Y(6) receptors stimulate while P2Y(13) receptors inhibits insulin secretion. Antagonists of P2Y(12) receptors, and potentially P2Y(1) receptors, are anti-thrombotic agents, and a P2Y(2)/P2Y(4) receptor agonist treats dry eye syndrome in Asia. P2Y receptor agonists are generally pro-inflammatory, and antagonists may eventually treat inflammatory conditions. This article reviews recent developments in P2Y receptor pharmacology (using synthetic agonists and antagonists), structure and biophysical properties (using X-ray crystallography, mutagenesis and modelling), physiological and pathophysiological roles, and present and potentially future therapeutic targeting.
WOS关键词SMOOTH-MUSCLE-CELLS ; P2Y(12) RECEPTOR ; NUCLEOTIDE RECEPTORS ; CONCISE GUIDE ; ACTIVE METABOLITE ; PURINERGIC REGULATION ; SELECTIVE AGONISTS ; EXTRACELLULAR ATP ; PLATELET P2Y(1) ; ANTAGONIST
资助项目NIDDK[ZIADK31116] ; Independent Research Fund Denmark[DFF-4002-00162] ; State of Saxony, Germany ; Integrated Research and Treatment Center (IFB) AdiposityDiseases (BMBF) ; German Research Foundation[FOR2372] ; German Research Foundation[GRK1873] ; German Research Foundation[SFB 1052]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者WILEY
WOS记录号WOS:000530811400001
源URL[http://119.78.100.183/handle/2S10ELR8/280070]  
专题中国科学院上海药物研究所
通讯作者Jacobson, Kenneth A.
作者单位1.Univ Bonn, Dept Pharmacol & Toxicol, Biomed Res Ctr, Bonn, Germany
2.Univ Leipzig, Rudolf Schonheimer Inst Biochem, Med Fac, Mol Biochem, Leipzig, Germany
3.Univ Bonn, Pharmaceut Inst, Dept Pharmaceut & Med Chem, Bonn, Germany
4.NIDDK, Lab Bioorgan Chem, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
5.Univ Complutense Madrid, Dept Bioquim & Biol Mol, Madrid, Spain
6.Univ Strasbourg, INSERM, EFS Grand Est, BPPS,UMR S 1255,FMTS, Strasbourg, France
7.Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland
8.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai, Peoples R China
9.Univ Copenhagen, Sect Cell Biol & Physiol, Dept Biol, Copenhagen, Denmark
10.Univ Leipzig, IFB AdiposityDis, Med Ctr, Leipzig, Germany
推荐引用方式
GB/T 7714
Jacobson, Kenneth A.,Delicado, Esmerilda G.,Gachet, Christian,et al. Update of P2Y receptor pharmacology: IUPHAR Review 27[J]. BRITISH JOURNAL OF PHARMACOLOGY,2020,177(11):2413-2433.
APA Jacobson, Kenneth A..,Delicado, Esmerilda G..,Gachet, Christian.,Kennedy, Charles.,von Kuegelgen, Ivar.,...&Mueller, Christa E..(2020).Update of P2Y receptor pharmacology: IUPHAR Review 27.BRITISH JOURNAL OF PHARMACOLOGY,177(11),2413-2433.
MLA Jacobson, Kenneth A.,et al."Update of P2Y receptor pharmacology: IUPHAR Review 27".BRITISH JOURNAL OF PHARMACOLOGY 177.11(2020):2413-2433.

入库方式: OAI收割

来源:上海药物研究所

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