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Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides

文献类型：期刊论文

作者Wang, Xiao-Feng2,3; Zhu, Zhengdan2,4; Hao, Ting-Ting1,5; Fang, Qiang-Qiang2,3; Jiang, Kun3; Qu, Shi-Jin3; Zuo, Jiang-Pin2,5; Zhu, Weiliang2,4; He, Shi-Jun2,5; Tan, Chang-Heng2,3
刊名BIOORGANIC CHEMISTRY
出版日期2020-06-01
卷号99页码:5
ISSN号0045-2068
关键词Sophora alopecuroides Alkaloids Cl-containing matrines Absolute configuration Immunosuppressive activity
DOI10.1016/j.bioorg.2020.103812
通讯作者He, Shi-Jun(heshijun@simm.ac.cn) ; Tan, Chang-Heng(chtan@simm.ac.cn)
英文摘要Alopecines A-E (1-5), five unusual matrine-type alkaloids featuring with an additional dichlorocyclopropane (1-3) or a di/tri-chloromethyl (4/5) attached on the D ring, were isolated from the seeds of Sophora alopecuroides. Their structures and absolute configurations were elucidated by extensive spectroscopic techniques, and X-ray diffraction analyses or time-dependent density functional theory-based electronic circular dichroism (TDDFT-ECD) calculations. Alkaloid 4 exhibited potent inhibitory effects on the proliferation of ConA-induced T lymphocytes or LPS-induced B cells with IC50 value of 3.98 or 3.74 mu M, respectively.
WOS关键词HBV ; DERIVATIVES ; PLANT
资助项目National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2018ZX09735001-002-005] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2019ZX09201001] ; Ministry of Science and Technology, China
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号WOS:000535442000005
源URL[http://119.78.100.183/handle/2S10ELR8/280084]  
专题新药研究国家重点实验室
通讯作者He, Shi-Jun; Tan, Chang-Heng
作者单位1.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Drug Discovery & Design Ctr, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xiao-Feng,Zhu, Zhengdan,Hao, Ting-Ting,et al. Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides[J]. BIOORGANIC CHEMISTRY,2020,99:5.
APA Wang, Xiao-Feng.,Zhu, Zhengdan.,Hao, Ting-Ting.,Fang, Qiang-Qiang.,Jiang, Kun.,...&Tan, Chang-Heng.(2020).Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides.BIOORGANIC CHEMISTRY,99,5.
MLA Wang, Xiao-Feng,et al."Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides".BIOORGANIC CHEMISTRY 99(2020):5.

入库方式： OAI收割

来源：上海药物研究所

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