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Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer

文献类型：期刊论文

作者Chang, Ya3; Jiang, Jizong4; Chen, Wu3; Yang, Wen5; Chen, Lili5; Chen, Pengyu5; Shen, Jianzhong3; Qian, Shizhi1; Zhou, Teng1; Wu, Linfeng2
刊名APPLIED MATERIALS TODAY
出版日期2020-03-01
卷号18页码:12
关键词Biomimetic delivery Metal-organic nanoparticle Disulfiram Copper diethyldithiocarbamate Microfluidic Breast cancer
ISSN号2352-9407
DOI10.1016/j.apmt.2019.100492
通讯作者Huang, Yongzhuo(yzhuang@simm.ac.cn) ; Li, Feng(FZL0023@auburn.edu)
英文摘要Disulfiram (DSF) is currently tested in several clinical trials for cancer treatment in combination with copper (Cu) ions. Usually, DSF and Cu are administered in two separate formulations. In the body, DSF and Cu ions form diethyldithiocarbamate copper complex [Cu(DDC)(2)] which has potent antitumor activities. However, the "two formulation" approach often achieved low Cu(DDC)(2) concentration at tumor regions and resulted in compromised anticancer efficacy. Therefore, preformed Cu(DDC)(2) complex administered in a single formulation will have better anticancer efficacy. However, the poor aqueous solubility of Cu(DDC)(2) is a significant challenge for its clinical use. In this work, a biomimetic nanoparticle formulation of Cu(DDC)(2) was produced with a novel SMILE (Stabilized Metal Ion Ligand complex) method developed in our laboratory to address the drug delivery challenges. The Metal-organic Nanoparticle (MON) is composed of Cu(DDC)(2) metal-organic complex core and surface decorated bovine serum albumin (BSA). Importantly, we designed a 3D-printed microfluidic device to further improve the fabrication of BSA/Cu(DDC)(2) MONs. This method could precisely control the MON preparation process and also has great potential for large scale production of Cu(DDC)(2) MON formulations. We also used a computational modeling approach to simulate the MON formation process in the microfluidic device. The optimized BSA/Cu(DDC)(2) MONs demonstrated good physicochemical properties. The MONs also showed potent antitumor activities in the breast cancer cell monolayers as well as the 3D-cultured tumor spheroids. The BSA/Cu(DDC)(2) MONs also effectively inhibited the growth of tumors in an orthotopic 4T1 breast tumor model. This current study provided a novel method to prepare a biomimetic MON formulation for DSF/Cu cancer therapy. (C) 2019 Elsevier Ltd. All rights reserved.
WOS关键词DELIVERY ; NANOMEDICINE
资助项目Auburn University start-up fund ; Launch Innovation Award ; National Science Foundation[CBET-1701363] ; National Institutes of Health[R35GM133795] ; NFSC[81673382] ; NFSC[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant New Drugs Development[2018ZX09711002010-002]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000530652300013
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/280095]  
专题新药研究国家重点实验室
通讯作者Huang, Yongzhuo; Li, Feng
作者单位1.Old Dominion Univ, Dept Mech & Aerosp Engn, Norfolk, VA 23529 USA
2.Univ Tennessee, Hlth Sci Ctr, Coll Dent, Memphis, TN 38163 USA
3.Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.Auburn Univ, Dept Mech Engn, Mat Res & Educ Ctr, Mat Engn, Auburn, AL 36849 USA
推荐引用方式
GB/T 7714		 Chang, Ya,Jiang, Jizong,Chen, Wu,et al. Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer[J]. APPLIED MATERIALS TODAY,2020,18:12.
APA Chang, Ya.,Jiang, Jizong.,Chen, Wu.,Yang, Wen.,Chen, Lili.,...&Li, Feng.(2020).Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer.APPLIED MATERIALS TODAY,18,12.
MLA Chang, Ya,et al."Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer".APPLIED MATERIALS TODAY 18(2020):12.

入库方式： OAI收割

来源：上海药物研究所

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