中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling

文献类型：期刊论文

作者Li Xue-Ying1,3,4; Tao Hong1,3; Jin Can1,3; Du Zhen-Yun1,3; Liao Wen-Feng1,3; Tang Qing-Jiu2; Ding Kan1,3
刊名CHINESE JOURNAL OF NATURAL MEDICINES
出版日期2020-04-01
卷号18期号:5页码:345-355
ISSN号2095-6975
关键词Cordycepin FGFR2 Apoptosis Pancreatic cancer Ras/Erk
DOI10.1016/S1875-5364(20)30041-8
通讯作者Tang Qing-Jiu() ; Ding Kan(dingkan@simm.ac.cn)
英文摘要Cordycepin (3'-deoxyadenosine) from Cordyceps militaris has been reported to have anti-tumor effects. However, the molecular target and mechanism underlying cordycepin impeding pancreatic cancer cell growth in vitro and in vivo remain vague. In this study, we reported functional target molecule of cordycepin which inhibited pancreatic cancer cells growth in vitro and in vivo. Cordycepin was confirmed to induce apoptosis by activating caspase-3, caspase-9 and cytochrome c. Further studies suggested that MAPK pathway was blocked by cordycepin via inhibiting the expression of Ras and the phosphorylation of Erk. Moreover, cordycepin caused S-phase arrest and DNA damage associated with activating Chk2 (checkpoint kinase 2) pathway and downregulating cyclin A2 and CDK2 phosphorylation. Very interestingly, we showed that cordycepin could bind to FGFR2 (K-D = 7.77 x 10(-9)) very potently to inhibit pancreatic cancer cells growth by blocking Ras/ErK pathway. These results suggest that cordycepin could potentially be a leading compound which targeted FGFR2 to inhibit pancreatic cells growth by inducing cell apoptosis and causing cell cycle arrest via blocking FGFR/Ras/ERK signaling for anti-pancreatic cancer new drug development.
WOS关键词CYTOCHROME-C RELEASE ; INDUCED APOPTOSIS ; PROTEIN ; ACTIVATION ; PATHWAY ; STATISTICS ; GENE ; BAX
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12010302] ; National Natural Science Foundation of China[31230022] ; Program of Shanghai Subject Chief Scientist[16XD1404500]
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种英语
出版者CHINESE JOURNAL NATURAL MEDICINES
WOS记录号WOS:000536286200002
源URL[http://119.78.100.183/handle/2S10ELR8/280098]  
专题中国科学院上海药物研究所
通讯作者Tang Qing-Jiu; Ding Kan
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Glycochemistry & Glycobiol Lab, Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China
推荐引用方式
GB/T 7714		 Li Xue-Ying,Tao Hong,Jin Can,et al. Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2020,18(5):345-355.
APA Li Xue-Ying.,Tao Hong.,Jin Can.,Du Zhen-Yun.,Liao Wen-Feng.,...&Ding Kan.(2020).Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling.CHINESE JOURNAL OF NATURAL MEDICINES,18(5),345-355.
MLA Li Xue-Ying,et al."Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling".CHINESE JOURNAL OF NATURAL MEDICINES 18.5(2020):345-355.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。