Targeting virulence factors as an antimicrobial approach: Pigment inhibitors
文献类型：期刊论文
| 作者 | Ni, Shuaishuai4; Li, Baoli2; Xu, Yixiang2; Mao, Fei2; Li, Xiaokang2; Lan, Lefu3 ; Zhu, Jin2; Li, Jian1,2
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| 刊名 | MEDICINAL RESEARCH REVIEWS
 |
| 出版日期 | 2020 |
| 卷号 | 40期号:1页码:293-338 |
| 关键词 | antimicrobial colored pathogens CrtN inhibitor staphyloxanthin virulence factor pigment |
| ISSN号 | 0198-6325 |
| DOI | 10.1002/med.21621 |
| 通讯作者 | Li, Jian(jianli@ecust.edu.cn) |
| 英文摘要 | The fascinating and dangerous colored pathogens contain unique chemically pigmented molecules, which give varied and efficient assistance as virulence factors to the crucial reproduction and growth of microbes. Therefore, multiple novel strategies and inhibitors have been developed in recent years that target virulence factor pigments. However, despite the importance and significance of this topic, it has not yet been comprehensively reviewed. Moreover, research groups around the world have made successful progress against antibacterial infections by targeting pigment production, including our serial works on the discovery of CrtN inhibitors against staphyloxanthin production in Staphylococcus aureus. On the basis of the previous achievements and recent progress of our group in this field, this article will be the first comprehensive review of pigment inhibitors against colored pathogens, especially S. aureus infections, and this article includes design strategies, representative case studies, advantages, limitations, and perspectives to guide future research. |
| WOS关键词 | PSEUDOMONAS-AERUGINOSA VIRULENCE ; QUORUM-SENSING INHIBITOR ; BETA-HEMATIN INHIBITION ; NONMELANIZED CRYPTOCOCCUS-NEOFORMANS ; DIAPOPHYTOENE DESATURASE INHIBITORS ; STAPHYLOCOCCUS-AUREUS ; METHICILLIN-RESISTANT ; PLASMODIUM-FALCIPARUM ; ANTIBACTERIAL DRUG ; IN-VITRO |
| 资助项目 | Shanghai Municipal Education Commission[14SG28] ; Shanghai Education Development Foundation[14SG28] ; National Special Fund for State Key Laboratory of Bioreactor Engineering[2060204] ; National Natural Science Foundation of China[21672064] ; National Key R&D Program of China[2017YFB0202600] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000534635500012 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280109]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Jian |
| 作者单位 | 1.East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai, Peoples R China 2.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Inst Canc, Longhua Hosp, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ni, Shuaishuai,Li, Baoli,Xu, Yixiang,et al. Targeting virulence factors as an antimicrobial approach: Pigment inhibitors[J]. MEDICINAL RESEARCH REVIEWS,2020,40(1):293-338. |
| APA | Ni, Shuaishuai.,Li, Baoli.,Xu, Yixiang.,Mao, Fei.,Li, Xiaokang.,...&Li, Jian.(2020).Targeting virulence factors as an antimicrobial approach: Pigment inhibitors.MEDICINAL RESEARCH REVIEWS,40(1),293-338. |
| MLA | Ni, Shuaishuai,et al."Targeting virulence factors as an antimicrobial approach: Pigment inhibitors".MEDICINAL RESEARCH REVIEWS 40.1(2020):293-338. |
入库方式： OAI收割
来源：上海药物研究所
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