The axial chirality hidden in vitamin D and its application in cocrystal prediction
文献类型：期刊论文
| 作者 | Guo, Mengfei2; Zhang, Zaiyong1; Chen, Zhaoqiang1; Ding, Qiaoce1; Lu, Liye1; Zhang, Qi1; Wang, Jian-Rong1 ; Mei, Xuefeng1
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| 刊名 | CRYSTENGCOMM
 |
| 出版日期 | 2020-05-14 |
| 卷号 | 22期号:18页码:3095-3099 |
| ISSN号 | 1466-8033 |
| DOI | 10.1039/d0ce00229a |
| 通讯作者 | Wang, Jian-Rong(jrwang@simm.ac.cn) ; Mei, Xuefeng(xuefengmei@simm.ac.cn) |
| 英文摘要 | The axial chirality of the non-planar conjugated triene in vitamin D-3 was uncovered for the first time. An ECD titration method was used not only for conformational analysis of vitamin D but also for sensitive detection of hydrogen-bonding interaction in solution. It provides a sensitive approach to predict cocrystal formation. |
| WOS关键词 | 1-ALPHA,25-DIHYDROXYVITAMIN-D3 ; CRYSTALLIZATION ; ATROPISOMERISM ; CONFORMATIONS |
| 资助项目 | Natural Science Foundation of Shanghai[18ZR1447900] ; Youth Innovation Promotion Association CAS[2016257] ; CAS Key Technology Talent Program ; SANOFI-SIBS Scholarship |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000536772800002 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280113]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Jian-Rong; Mei, Xuefeng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China 2.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Mengfei,Zhang, Zaiyong,Chen, Zhaoqiang,et al. The axial chirality hidden in vitamin D and its application in cocrystal prediction[J]. CRYSTENGCOMM,2020,22(18):3095-3099. |
| APA | Guo, Mengfei.,Zhang, Zaiyong.,Chen, Zhaoqiang.,Ding, Qiaoce.,Lu, Liye.,...&Mei, Xuefeng.(2020).The axial chirality hidden in vitamin D and its application in cocrystal prediction.CRYSTENGCOMM,22(18),3095-3099. |
| MLA | Guo, Mengfei,et al."The axial chirality hidden in vitamin D and its application in cocrystal prediction".CRYSTENGCOMM 22.18(2020):3095-3099. |
入库方式： OAI收割
来源：上海药物研究所
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