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New Steroids from the South China Sea Soft Coral Lobophytum sp.

文献类型：期刊论文

作者Ye, Fei3,4; Zhou, Yu-Bo4; Li, Jia2,3,4; Gu, Yu-Cheng1; Guo, Yue-Wei2,3,4; Li, Xu-Wen2,3,4
刊名CHEMISTRY & BIODIVERSITY
出版日期2020-05-27
页码6
ISSN号1612-1872
关键词soft coral Lobophytum steroids biological activity NF-kappa B
DOI10.1002/cbdv.202000214
通讯作者Guo, Yue-Wei(xwli@simm.ac.cn) ; Li, Xu-Wen(ywguo@simm.ac.cn)
英文摘要Two new steroids, (22R,23S)-3 beta-hydroxy-23-methyl-17,20-epoxyergost-5-en-22-yl acetate and (22R,23S)-5-hydroperoxy-23-methyl-5 alpha-17,20-epoxyergost-6-ene-3 beta,22-diol, were isolated from the South China Sea soft coral Lobophytum sp., together with two related known ones. The structures of all compounds were elucidated by extensive spectroscopic analysis and by comparing their spectral data with those previously reported. The structure of (22R,23S)-3 beta-hydroxy-23-methyl-17,20-epoxyergost-5-en-22-yl acetate was further confirmed through chemical correlation. All the isolates were evaluated for the in vitro inhibitory activity against NF-kappa B, a potential target for the treatment of cancer, and (22R,23S)-5-hydroperoxy-23-methyl-5 alpha-17,20-epoxyergost-6-ene-3 beta,22-diol exhibited moderate inhibition activity with IC50 value of 8.96 mu g/mL.
WOS关键词KAPPA-B
资助项目National Key Research and Development Program of China[2018YFC0310903] ; Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; NSFC/CNRS joint project[81811530284] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Chinese Academy of Sciences[2016258] ; SA-SIBS Scholarship Program
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000535582300001
源URL[http://119.78.100.183/handle/2S10ELR8/280122]  
专题新药研究国家重点实验室
通讯作者Guo, Yue-Wei; Li, Xu-Wen
作者单位1.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
2.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Ye, Fei,Zhou, Yu-Bo,Li, Jia,et al. New Steroids from the South China Sea Soft Coral Lobophytum sp.[J]. CHEMISTRY & BIODIVERSITY,2020:6.
APA Ye, Fei,Zhou, Yu-Bo,Li, Jia,Gu, Yu-Cheng,Guo, Yue-Wei,&Li, Xu-Wen.(2020).New Steroids from the South China Sea Soft Coral Lobophytum sp..CHEMISTRY & BIODIVERSITY,6.
MLA Ye, Fei,et al."New Steroids from the South China Sea Soft Coral Lobophytum sp.".CHEMISTRY & BIODIVERSITY (2020):6.

入库方式： OAI收割

来源：上海药物研究所

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