Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata
文献类型：期刊论文
| 作者 | Zhou, Bin4; Wu, Yan4; Gan, Lishe2; Dalal, Seema5; Cassera, Maria B.1,3; Yue, Jianmin4
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| 刊名 | CHINESE JOURNAL OF CHEMISTRY
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| 出版日期 | 2020-05-12 |
| 页码 | 5 |
| ISSN号 | 1001-604X |
| 关键词 | Natural products Diarymethane derivatives Diarymethane derivative dimers Structure elucidation Antiplasmodial activity |
| DOI | 10.1002/cjoc.202000094 |
| 通讯作者 | Yue, Jianmin(jmyue@simm.ac.cn) |
| 英文摘要 | .Summary of main observation and conclusion Securines A-E, three dimeric diarymethane derivatives (1-3) and two enantiomeric diarymethane derivative monomers (4 and 5), were isolated and characterized from the medicinal plant Securidaca inappendiculata. Compounds 1 and 2 are a pair of enantiomeric diarymethane derivative dimers, and compound 3 is a mesomeric diarymethane derivative dimer. Their structures were determined by a combination of spectroscopic data, X-ray crystallography, electronic circular dichroism (ECD) analysis, and computational ECD calculations. Dimeric compounds 1-3 showed moderate antiplasmodial activities with IC50 values of 0.9, 1.4, and 1.5 mu M, respectively. |
| WOS关键词 | A-C ; XANTHONES ; DIMERS ; ROOTS ; STEMS |
| 资助项目 | National Natural Science Foundation of China[21532007] ; Drug Innovation Major Project of China[2018ZX09711001-001-005] ; Biological Resources Program, CAS of China[KFJ-BRP-008] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000531552400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280206]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jianmin |
| 作者单位 | 1.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Athens, GA 30602 USA 2.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China 3.Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 5.Virginia Tech, Dept Biochem, MC 0308, Blacksburg, VA 24061 USA |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Wu, Yan,Gan, Lishe,et al. Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata[J]. CHINESE JOURNAL OF CHEMISTRY,2020:5. |
| APA | Zhou, Bin,Wu, Yan,Gan, Lishe,Dalal, Seema,Cassera, Maria B.,&Yue, Jianmin.(2020).Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata.CHINESE JOURNAL OF CHEMISTRY,5. |
| MLA | Zhou, Bin,et al."Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata".CHINESE JOURNAL OF CHEMISTRY (2020):5. |
入库方式： OAI收割
来源：上海药物研究所
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