中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery

文献类型:期刊论文

作者Duan, Wenjia4; Yue, Qi5; Liu, Ying6; Zhang, Yunfei4; Guo, Qinghua4; Wang, Cong4; Yin, Shujie4; Fan, Dandan4; Xu, Wenjing6; Zhuang, Jianxian4
刊名CHEMICAL SCIENCE
出版日期2020-05-07
卷号11期号:17页码:4397-4402
ISSN号2041-6520
DOI10.1039/d0sc00844c
通讯作者Mao, Ying(maoying@fudan.edu.cn) ; Zhang, Xiao-Yong(xiaoyong_zhang@fudan.edu.cn) ; Li, Cong(congli@fudan.edu.cn)
英文摘要Surgery remains the mainstay for most solid tumor treatments. However, surgeons face challenges in intra-operatively identifying invasive tumor margins due to their infiltrative nature. Incomplete excision usually leads to early recurrence, while aggressive resection may injure adjacent functional tissues. Herein, we report a pH responsive ratiometric surface-enhanced Raman scattering (SERRS) probe that determined physiological pHs with a high sensitivity and tissue penetration depth via an innovative mechanism named spatial orientation induced intramolecular energy transfer (SOIET). Due to the positive correlation between tumor acidity and malignancy, an acidic margin-guided surgery strategy was implemented in live animal models by intra-operatively assessing tissue pH/malignancy of the suspicious tissues in tumor cutting edges. This surgery remarkably extended the survival of animal models and minimized their post-surgical complications, showing promise in precisely identifying invasive tumor boundaries and achieving a balance between maximum tumor debulking and minimal functional impairment.
WOS关键词SERS NANOPARTICLES ; SPECTROSCOPY
资助项目National Natural Science Foundation of China[81771895] ; National Natural Science Foundation of China[81572483] ; National Natural Science Foundation of China[81611130223] ; National Natural Science Foundation of China[81873893] ; National Natural Science Foundation of China[81602178] ; National Natural Science Foundation of China[81671753] ; National Natural Science Foundation of China[81771890] ; National Natural Science Foundation of China[91859106] ; Program of Shanghai Science and Technology Committee[19431900400] ; Program of Shanghai Science and Technology Committee[18441900600] ; Program of Shanghai Science and Technology Committee[13411950201] ; Program of Shanghai Science and Technology Committee[16JC1420100] ; Fudan-SIMM Joint Research Fund[20173001] ; One Hundred Talent Program of the Chinese Academy of Sciences ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX01] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; 111 Project[B18015] ; Zhangjiang Lab
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000532365500009
源URL[http://119.78.100.183/handle/2S10ELR8/280226]  
专题中国科学院上海药物研究所
通讯作者Mao, Ying; Zhang, Xiao-Yong; Li, Cong
作者单位1.Beijing Inst Technol, Sch Comp Sci & Technol, Bejing Lab Intelligent Informat Technol, Beijing 100081, Peoples R China
2.Univ Torino, Hlth Sci Mol Imaging Ctr, Dept Mol Biotechnol, Via Nizza 52, I-10126 Turin, Italy
3.Xidian Univ, Sch Lift Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuroimaging, Xian 710026, Shaanxi, Peoples R China
4.Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China
5.Fudan Univ, Dept Neurosurg, Huashan Hosp, Shanghai 200040, Peoples R China
6.Fudan Univ, Minist Educ, Inst Sci & Technol Brain Inspired Intelligence, Key Lab Computat Neurosci & Brain Inspired Intell, Shanghai 200433, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Duan, Wenjia,Yue, Qi,Liu, Ying,et al. A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery[J]. CHEMICAL SCIENCE,2020,11(17):4397-4402.
APA Duan, Wenjia.,Yue, Qi.,Liu, Ying.,Zhang, Yunfei.,Guo, Qinghua.,...&Li, Cong.(2020).A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery.CHEMICAL SCIENCE,11(17),4397-4402.
MLA Duan, Wenjia,et al."A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery".CHEMICAL SCIENCE 11.17(2020):4397-4402.

入库方式: OAI收割

来源:上海药物研究所

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