A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery
文献类型:期刊论文
作者 | Duan, Wenjia4; Yue, Qi5; Liu, Ying6; Zhang, Yunfei4; Guo, Qinghua4; Wang, Cong4; Yin, Shujie4; Fan, Dandan4; Xu, Wenjing6; Zhuang, Jianxian4 |
刊名 | CHEMICAL SCIENCE |
出版日期 | 2020-05-07 |
卷号 | 11期号:17页码:4397-4402 |
ISSN号 | 2041-6520 |
DOI | 10.1039/d0sc00844c |
通讯作者 | Mao, Ying(maoying@fudan.edu.cn) ; Zhang, Xiao-Yong(xiaoyong_zhang@fudan.edu.cn) ; Li, Cong(congli@fudan.edu.cn) |
英文摘要 | Surgery remains the mainstay for most solid tumor treatments. However, surgeons face challenges in intra-operatively identifying invasive tumor margins due to their infiltrative nature. Incomplete excision usually leads to early recurrence, while aggressive resection may injure adjacent functional tissues. Herein, we report a pH responsive ratiometric surface-enhanced Raman scattering (SERRS) probe that determined physiological pHs with a high sensitivity and tissue penetration depth via an innovative mechanism named spatial orientation induced intramolecular energy transfer (SOIET). Due to the positive correlation between tumor acidity and malignancy, an acidic margin-guided surgery strategy was implemented in live animal models by intra-operatively assessing tissue pH/malignancy of the suspicious tissues in tumor cutting edges. This surgery remarkably extended the survival of animal models and minimized their post-surgical complications, showing promise in precisely identifying invasive tumor boundaries and achieving a balance between maximum tumor debulking and minimal functional impairment. |
WOS关键词 | SERS NANOPARTICLES ; SPECTROSCOPY |
资助项目 | National Natural Science Foundation of China[81771895] ; National Natural Science Foundation of China[81572483] ; National Natural Science Foundation of China[81611130223] ; National Natural Science Foundation of China[81873893] ; National Natural Science Foundation of China[81602178] ; National Natural Science Foundation of China[81671753] ; National Natural Science Foundation of China[81771890] ; National Natural Science Foundation of China[91859106] ; Program of Shanghai Science and Technology Committee[19431900400] ; Program of Shanghai Science and Technology Committee[18441900600] ; Program of Shanghai Science and Technology Committee[13411950201] ; Program of Shanghai Science and Technology Committee[16JC1420100] ; Fudan-SIMM Joint Research Fund[20173001] ; One Hundred Talent Program of the Chinese Academy of Sciences ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX01] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; 111 Project[B18015] ; Zhangjiang Lab |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000532365500009 |
源URL | [http://119.78.100.183/handle/2S10ELR8/280226] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Mao, Ying; Zhang, Xiao-Yong; Li, Cong |
作者单位 | 1.Beijing Inst Technol, Sch Comp Sci & Technol, Bejing Lab Intelligent Informat Technol, Beijing 100081, Peoples R China 2.Univ Torino, Hlth Sci Mol Imaging Ctr, Dept Mol Biotechnol, Via Nizza 52, I-10126 Turin, Italy 3.Xidian Univ, Sch Lift Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuroimaging, Xian 710026, Shaanxi, Peoples R China 4.Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China 5.Fudan Univ, Dept Neurosurg, Huashan Hosp, Shanghai 200040, Peoples R China 6.Fudan Univ, Minist Educ, Inst Sci & Technol Brain Inspired Intelligence, Key Lab Computat Neurosci & Brain Inspired Intell, Shanghai 200433, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Duan, Wenjia,Yue, Qi,Liu, Ying,et al. A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery[J]. CHEMICAL SCIENCE,2020,11(17):4397-4402. |
APA | Duan, Wenjia.,Yue, Qi.,Liu, Ying.,Zhang, Yunfei.,Guo, Qinghua.,...&Li, Cong.(2020).A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery.CHEMICAL SCIENCE,11(17),4397-4402. |
MLA | Duan, Wenjia,et al."A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery".CHEMICAL SCIENCE 11.17(2020):4397-4402. |
入库方式: OAI收割
来源:上海药物研究所
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