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Calcitriol-Loaded Dual-pH-Sensitive Micelle Counteracts Pro-Metastasis Effect of Paclitaxel in Triple-Negative Breast Cancer Therapy

文献类型：期刊论文

作者Zheng, Zhong2,3,5,6; Lang, Tianqun2,4,6; Huang, Xin2,4,6; Wang, Guanru; Lee, Robert J.1,5; Teng, Lesheng5; Yin, Qi2,3,4,6; Li, Yaping2,4,6
刊名ADVANCED HEALTHCARE MATERIALS
出版日期2020-05-17
页码12
关键词breast cancer calcitriol metastasis micelles pH-sensitive micelles
ISSN号2192-2640
DOI10.1002/adhm.202000392
通讯作者Teng, Lesheng(tenglesheng@jlu.edu.cn) ; Yin, Qi(qyin@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要The therapy of triple-negative breast cancer (TNBC) relies on chemotherapy basing on cytotoxic agents, including paclitaxel (PTX). Unfortunately, PTX will facilitate the invasion of cancer cells and the formation of metastases. To counteract pro-metastasis of PTX in TNBC therapy, in this work, calcitriol (CTL) is delivered along with PTX by a dual-pH-sensitive micelle. The PTX/CTL-co-loaded dual-pH-sensitive micelle (PCDM) can switch its surface charge from negative to positive at the tumor tissue and release PTX and CTL inside the lysosomes because of the structure change of the polymers composing PCDM under the acidic condition. This property makes PCDM able to escape from mononuclear-phagocyte system clearance and easy to enter tumor cells. PCDM efficiently suppresses the 4T1 primary tumor growth in mice and inhibits lung metastasis, due to downregulation of matrix metalloproteinase-9 and BCL-2 levels, upregulation of E-cadherin level, and counteracting the PTX-induced elevation of C-C motif chemokine ligand 2 (CCL2) and Ly6C(+) monocytes levels by CTL. PCDM shows good biocompatibility without promoting the serum calcium level. Therefore, the combination of PTX and CTL based on this pH-sensitive micelle is promising for the TNBC treatment.
WOS关键词TARGETED DRUG-DELIVERY ; TUMOR ; ANTICANCER ; MECHANISMS ; SYSTEMS
资助项目National Natural Science Foundation of China[81871471] ; National Natural Science Foundation of China[81630052] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Natural Science Foundation of Shanghai[19ZR1479900] ; Key Scientific Research Program of CAS[QYZDJ-SSW-SMC020] ; SA-SIBS Scholarship Program
WOS研究方向Engineering ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000533236200001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/280242]  
专题新药研究国家重点实验室
通讯作者Teng, Lesheng; Yin, Qi; Li, Yaping
作者单位1.Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA
2.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
5.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China
6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zheng, Zhong,Lang, Tianqun,Huang, Xin,et al. Calcitriol-Loaded Dual-pH-Sensitive Micelle Counteracts Pro-Metastasis Effect of Paclitaxel in Triple-Negative Breast Cancer Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2020:12.
APA Zheng, Zhong.,Lang, Tianqun.,Huang, Xin.,Wang, Guanru.,Lee, Robert J..,...&Li, Yaping.(2020).Calcitriol-Loaded Dual-pH-Sensitive Micelle Counteracts Pro-Metastasis Effect of Paclitaxel in Triple-Negative Breast Cancer Therapy.ADVANCED HEALTHCARE MATERIALS,12.
MLA Zheng, Zhong,et al."Calcitriol-Loaded Dual-pH-Sensitive Micelle Counteracts Pro-Metastasis Effect of Paclitaxel in Triple-Negative Breast Cancer Therapy".ADVANCED HEALTHCARE MATERIALS (2020):12.

入库方式： OAI收割

来源：上海药物研究所

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