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Hyperinoids A and B, two polycyclic meroterpenoids from Hypericum patulum

文献类型：期刊论文

作者Jia, Xinyu2,3; Wu, Yongmei1; Lei, Chun3; Yu, Yanyan1; Li, Jianqi2; Li, Jingya1; Hou, Aijun3
刊名CHINESE CHEMICAL LETTERS
出版日期2020-05-01
卷号31期号:5页码:1263-1266
ISSN号1001-8417
关键词Meroterpenoids Hyperinoids A and B Anti-inflammation Hypericum patulum Guttiferae
DOI10.1016/j.cclet.2019.10.014
通讯作者Li, Jianqi(lijianqb@126.com) ; Li, Jingya(jyli@simm.ac.cn) ; Hou, Aijun(ajhou@shmu.edu.cn)
英文摘要Hyperinoids A (1) and B (2), two prenylated acylphloroglucinol related meroterpenoids, were isolated from Hypericum patulum. Compound 1 incorporates an unprecedented 11,12-dioxatetracyclo [5.4.3.0(1,7).0(4,)(14)]tetradecane system, while 2 possesses a unique 10,11-dioxatetracyclo[5.3.3.0(1,7).0(4,)(13)] tridecane system. Their structures were established by spectroscopic analysis and X-ray crystallographic data. Compounds 1 and 2 were identified as potent NF-kappa B inhibitors and suppressed the LPS-induced inflammatory responses in RAW 246.7 macrophages and primary mouse BMDM cells (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
WOS关键词PAIRS
资助项目Fudan-SIMM Joint Research Fund[FU-SIMM20181011]
WOS研究方向Chemistry
语种英语
出版者ELSEVIER SCIENCE INC
WOS记录号WOS:000531056900046
源URL[http://119.78.100.183/handle/2S10ELR8/280246]  
专题中国科学院上海药物研究所
通讯作者Li, Jianqi; Li, Jingya; Hou, Aijun
作者单位1.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Shanghai Inst Pharmaceut Ind, Shanghai 201203, Peoples R China
3.Fudan Univ, Sch Pharm, State Key Lab Med Neurobiol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Jia, Xinyu,Wu, Yongmei,Lei, Chun,et al. Hyperinoids A and B, two polycyclic meroterpenoids from Hypericum patulum[J]. CHINESE CHEMICAL LETTERS,2020,31(5):1263-1266.
APA Jia, Xinyu.,Wu, Yongmei.,Lei, Chun.,Yu, Yanyan.,Li, Jianqi.,...&Hou, Aijun.(2020).Hyperinoids A and B, two polycyclic meroterpenoids from Hypericum patulum.CHINESE CHEMICAL LETTERS,31(5),1263-1266.
MLA Jia, Xinyu,et al."Hyperinoids A and B, two polycyclic meroterpenoids from Hypericum patulum".CHINESE CHEMICAL LETTERS 31.5(2020):1263-1266.

入库方式： OAI收割

来源：上海药物研究所

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