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Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis

文献类型：期刊论文

作者Wu, Zhuona4,5; Zeng, Hairong1; Zhang, Lili4; Pu, Yiqiong5; Li, Suyun6; Yuan, Yi1; Zhang, Tong4,5; Wang, Bing2,3,4
刊名INFLAMMATION
出版日期2020-05-09
页码13
关键词patchouli alcohol ulcerative colitis intestinal integrity anti-inflammatory
ISSN号0360-3997
DOI10.1007/s10753-020-01219-8
通讯作者Yuan, Yi(yuanyi0625@163.com) ; Zhang, Tong(zhangtdmj@hotmail.com) ; Wang, Bing(bwang@simm.ac.cn)
英文摘要Ulcerative colitis (UC) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract, characterized by diarrhea, hematochezia, abdominal distension, and abdominal pain. The perpetuation of inflammation and the impairment of the intestinal barrier are part of the main courses of UC, responsible for the deteriorating inflammatory condition. Patchouli alcohol (PA), extracted from Pogostemon cablin Benth., is employed to treat both inflammation and intestinal barrier damage. Its curative effect on UC was testified firstly by TNBS-induced UC, a chemically induced colitis, and further tested by DSS-induced UC, an acute attack stage of UC in which the clinical course of human UC occurs frequently. PA reduced the levels of TNF-alpha, IFN-gamma, IL-1 beta, IL-6, and IL-17 in serum and decreased the mRNA expression of pro-inflammatory cytokines (e.g., iNOS, COX-2, TNF-alpha, IL-1 beta, and IL-6). Concurrently, PA upregulated the expression of tight junction protein (e.g., ZO-1, ZO-2, claudin-1, and occludin) and the mRNA of mucin-1 and mucin-2 in both animal models. Further, PA ameliorated both histological damage and clinical parameters. Thus, PA could credibly reduce the expression of pro-inflammatory cytokines, protect the integrity of intestinal epithelial barrier, and repair the macroscopic colon lesions in both colitis models.
WOS关键词ANTIINFLAMMATORY ACTIVITY ; POGOSTEMONIS HERBA ; COLORECTAL-CANCER ; BOWEL-DISEASE ; RAW264.7 ; STRESS ; RISK ; MICE ; OIL
资助项目Program of Shanghai Committee of Science and Technology of China[17401902300] ; Program of Shanghai Academic/Technology Research Leader of China[18XD1403700]
WOS研究方向Cell Biology ; Immunology
语种英语
WOS记录号WOS:000531197300001
出版者SPRINGER/PLENUM PUBLISHERS
源URL[http://119.78.100.183/handle/2S10ELR8/280281]  
专题新药研究国家重点实验室
通讯作者Yuan, Yi; Zhang, Tong; Wang, Bing
作者单位1.Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Pharm, 164 Lanxi Rd, Shanghai 200062, Peoples R China
2.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China
5.Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, 1200 Cailun Rd, Shanghai 201203, Peoples R China
6.Shanghai Univ Tradit Chinese Med, Sch Basic Med Sci, 1200 Cailun Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Zhuona,Zeng, Hairong,Zhang, Lili,et al. Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis[J]. INFLAMMATION,2020:13.
APA Wu, Zhuona.,Zeng, Hairong.,Zhang, Lili.,Pu, Yiqiong.,Li, Suyun.,...&Wang, Bing.(2020).Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis.INFLAMMATION,13.
MLA Wu, Zhuona,et al."Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis".INFLAMMATION (2020):13.

入库方式： OAI收割

来源：上海药物研究所

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