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Palladium-catalyzed meta-C-H bond iodination of arenes with I-2

文献类型：期刊论文

作者Liu, Min1,2,3; Li, Ling-Jun1,2,3; Zhang, Jun1,4; Xu, Hui1,2,3; Dai, Hui-Xiong1,2,3
刊名CHINESE CHEMICAL LETTERS
出版日期2020-05-01
卷号31期号:5页码:1301-1304
关键词Palladium catalysis meta-C-H iodination Pyridine-based template Practical ester linkages Molecular I-2
ISSN号1001-8417
DOI10.1016/j.cclet.2019.09.057
通讯作者Xu, Hui(xuhui2018@simm.ac.cn) ; Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要Palladium-catalyzed highly meta-selective C-H iodination of phenylacetic acid, benzylphosphonate and benzylsulfonate scaffolds with molecular I-2 is developed using a pyridine-type template. The practical ester linkages enable the directing template easily installed and readily removed. The substrate scope is broad, and alkyl, methoxyl, trifluomethyl, and halo substituents are compatible with this reaction. Further transformations of ibuprofen iodide intermediates by Pd-catalyzed C-C and C-heteroatom bond formation illustrate the broad utility of this method. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
WOS关键词REGIOSELECTIVE HALOGENATION ; COUPLING REACTIONS ; N-OXIDES ; ACTIVATION ; BORYLATION ; FUNCTIONALIZATION ; LIGAND ; ARYL ; BROMINATION ; OLEFINATION
资助项目National Natural Science Foundation of China[21772211] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; State Key Laboratory of Natural and Biomimetic Drugs ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000531056900054
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/280317]  
专题中国科学院上海药物研究所
通讯作者Xu, Hui; Dai, Hui-Xiong
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Min,Li, Ling-Jun,Zhang, Jun,et al. Palladium-catalyzed meta-C-H bond iodination of arenes with I-2[J]. CHINESE CHEMICAL LETTERS,2020,31(5):1301-1304.
APA Liu, Min,Li, Ling-Jun,Zhang, Jun,Xu, Hui,&Dai, Hui-Xiong.(2020).Palladium-catalyzed meta-C-H bond iodination of arenes with I-2.CHINESE CHEMICAL LETTERS,31(5),1301-1304.
MLA Liu, Min,et al."Palladium-catalyzed meta-C-H bond iodination of arenes with I-2".CHINESE CHEMICAL LETTERS 31.5(2020):1301-1304.

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来源：上海药物研究所

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