Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities
文献类型：期刊论文
| 作者 | Xu, Fangfang4,5; Gao, Meihua1; Li, Hua1; Han, Xiaodong4; Zhang, Xiaoqi2; Li, Yaolan2; Guo, De-an3,4 ; Liu, Bo4,5
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2020-06-01 |
| 卷号 | 143页码:6 |
| 关键词 | Hovenia dulcis Thunb. Bisflavonol Flavonoids Anti-RSV activity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2020.104587 |
| 通讯作者 | Li, Hua(lihua@gdidc.org.cn) ; Guo, De-an(daguo@simm.ac.cn) ; Liu, Bo(doctliu@263.net) |
| 英文摘要 | Three novel bisflavonol derivatives, Hovenianins A-C, along with 12 known flavonoids were isolated and identified from the seeds of Hovenia dulcis Thunb. Their structures were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and electronic circular dichroism experiments. Hovenianin A (1) was the first dimer of flavonol linked dihydroflavonol via the B rings at C-2' and C-2'''positions to be found in nature. While Hovenianins BC (2-3) were a pair of diastereoisomeric bis-dihydroflavonols firstly reported in the Hovenia genus. The in vitro antiviral activity against respiratory syncytium virus (RSV) were evaluated by cytopathic effect (CPE) reduction assay. As a result, compounds 4, 5, and 10 displayed better antiviral effect against RSV A2 strains. |
| 资助项目 | National Natural Science Foundation of China[81703379] ; National Natural Science Foundation of China[U1801287] ; Science and Technology Planning Project of Guangdong Province[2017B030314166] ; Science and Technology Planning Project of Guangdong Province[2018B020207008] ; Special Funds for Inheriting and Developing the Traditional Chinese Medicine from TCM Bureau of Guangdong Province[20181121] ; Special Funds for Inheriting and Developing the Traditional Chinese Medicine from TCM Bureau of Guangdong Province[20191137] ; Special Funds for Inheriting and Developing the Traditional Chinese Medicine from TCM Bureau of Guangdong Province[20191142] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2016QJ05] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2015MS03] ; Key Project of High-level University Construction of Guangzhou University of Chinese Medicine[XK2018019] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000532686800035 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280367]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Hua; Guo, De-an; Liu, Bo |
| 作者单位 | 1.Guangdong Inst Drug Control, Guangzhou 510663, Peoples R China 2.Jinan Univ, Coll Pharm, Guangdong Prov Engn Res Ctr Modernizat TCM, Guangzhou 510632, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Guangzhou Univ Chinese Med, Second Clin Medicial Coll, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou 510006, Peoples R China 5.Guangzhou Key Lab Chiral Res Act Components Tradi, Guangzhou 510006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Fangfang,Gao, Meihua,Li, Hua,et al. Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities[J]. FITOTERAPIA,2020,143:6. |
| APA | Xu, Fangfang.,Gao, Meihua.,Li, Hua.,Han, Xiaodong.,Zhang, Xiaoqi.,...&Liu, Bo.(2020).Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities.FITOTERAPIA,143,6. |
| MLA | Xu, Fangfang,et al."Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities".FITOTERAPIA 143(2020):6. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。