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Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy

文献类型：期刊论文

作者Zhu, Qiwen1,4; Saeed, Madiha1,4; Song, Rundi1,4; Sun, Tao2; Jiang, Chen2; Yu, Haijun1,3,4
刊名CHINESE CHEMICAL LETTERS
出版日期2020-05-01
卷号31期号:5页码:1051-1059
关键词Cancer therapy Drug delivery systems Dynamic covalent chemistry Acid-responsive Reduction-responsive
ISSN号1001-8417
DOI10.1016/j.cclet.2019.12.002
通讯作者Yu, Haijun(hjyu@simm.ac.cn)
英文摘要Drug delivery systems (DDSs) are of paramount importance to deliver drugs at the intended targets, e.g., tumor cells or tissue by prolonging blood circulation and optimizing the pharmaceutical profiles. However, the therapeutic efficacy of DDSs is severely impaired by insufficient or non-specific drug release. Dynamic chemical bonds having stimuli-liable properties are therefore introduced into DDSs for regulating the drug release kinetics. This review summarizes the recent advances of dynamic covalent chemistry in the DDSs for improving cancer therapy. The review discusses the constitutions of the major classes of dynamic covalent bonds, and the respective applications in the tumor-targeted DDSs which are based on the different responsive mechanisms, including acid-activatable and reduction-activatable. Furthermore, the review also discusses combination strategies of dual dynamic covalent bonds which can response to the complex tumor microenvironment much more accurately, and then summarizes and analyzes the prospects for the application of dynamic covalent chemistry in DDSs. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
WOS关键词LINKED INJECTABLE HYDROGELS ; GENE DELIVERY ; CONTROLLED-RELEASE ; NANOPARTICLES ; ANTIBODY ; PH ; DEGRADATION ; DEXTRAN ; CELLS ; TRANSFECTION
资助项目National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31622025] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2014218] ; Fudan University[FU-SIMM-20182006] ; Shanghai Institute of Materia Medica, CAS[FU-SIMM-20182006] ; Open Project Program of Key Lab of Smart Drug Delivery (Ministry of Education), Department of Pharmaceutics, School of Pharmacy, Fudan University, China
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000531056900002
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/280375]  
专题新药研究国家重点实验室
通讯作者Yu, Haijun
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Fudan Univ, State Key Lab Med Neurobiol, Dept Pharmaceut, Key Lab Smart Drug Delivery,Minist Educ,Sch Pharm, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Qiwen,Saeed, Madiha,Song, Rundi,et al. Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy[J]. CHINESE CHEMICAL LETTERS,2020,31(5):1051-1059.
APA Zhu, Qiwen,Saeed, Madiha,Song, Rundi,Sun, Tao,Jiang, Chen,&Yu, Haijun.(2020).Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy.CHINESE CHEMICAL LETTERS,31(5),1051-1059.
MLA Zhu, Qiwen,et al."Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy".CHINESE CHEMICAL LETTERS 31.5(2020):1051-1059.

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来源：上海药物研究所

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