Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer
文献类型：期刊论文
| 作者 | Liu Xueling; Wang Bobo; Wang Yi; Wang Yuxiang; Yang Chunhao; Tan Cun; Zhang Xi; He Qiaojun; Ding Jian; Meng Linghua |
| 刊名 | signaltransductionandtargetedtherapy
 |
| 出版日期 | 2019 |
| 卷号 | 4期号:4页码:295 |
| ISSN号 | 2095-9907 |
| 英文摘要 | Targeting PI3K is a promising approach for cancer therapy, and the PI3Kα-selective inhibitor alpelisib has been approved for breast cancer treatment.1–3 However, the development of acquired resistance poses a significant clinical challenge. Loss of PTEN and activation of mTOR, CDK4/6, or PIM have been reported to mediate acquired resistance to alpelisib.4–7 The mechanisms leading to resistance to PI3Kα inhibitors appear to be different under different circumstances, and the aforementioned strategies may be beneficial for a particular group of patients. New strategies to overcome acquired resistance in a broad spectrum of patients need to be discovered. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280394]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Division of Anti-Tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences 2.Division of Anti-Tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences 3.College of Pharmaceutical Sciences,Zhejiang University 4.University of Chinese Academy of Sciences 5.Division of Anti-Tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences 6.Division of Anti-Tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences 7.Division of Anti-Tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences 8.Division of Anti-Tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences 9.Department of Medicinal Chemistry,Shanghai Institute of Materia Medica,Chinese Academy of Sciences 10.Department of Medicinal Chemistry,Shanghai Institute of Materia Medica,Chinese Academy of Sciences |
| 推荐引用方式 GB/T 7714 | Liu Xueling,Wang Bobo,Wang Yi,et al. Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer[J]. signaltransductionandtargetedtherapy,2019,4(4):295. |
| APA | Liu Xueling.,Wang Bobo.,Wang Yi.,Wang Yuxiang.,Yang Chunhao.,...&Meng Linghua.(2019).Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer.signaltransductionandtargetedtherapy,4(4),295. |
| MLA | Liu Xueling,et al."Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer".signaltransductionandtargetedtherapy 4.4(2019):295. |
入库方式： OAI收割
来源：上海药物研究所
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