Structure of formylpeptide receptor 2-G i complex reveals insights into ligand recognition and signaling
文献类型：期刊论文
| 作者 | Youwen Zhuang; Heng Liu; X. Edward Zhou; Ravi Kumar Verma; Parker W. de Waal; Wonjo Jang; Ting-Hai Xu; Lei Wang; Xing Meng; Gongpu Zhao |
| 刊名 | naturecommunications
 |
| 出版日期 | 2020 |
| 卷号 | 11期号:1页码:1 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-020-14728-9 |
| 英文摘要 | Formylpeptide receptors (FPRs) as G protein-coupled receptors (GPCRs) can recognize formylpeptides derived from pathogens or host cells to function in host defense and cell clearance. In addition, FPRs, especially FPR2, can also recognize other ligands with a large chemical diversity generated at different stages of inflammation to either promote or resolve inflammation in order to maintain a balanced inflammatory response. The mechanism underlying promiscuous ligand recognition and activation of FPRs is not clear. Here we report a cryo-EM structure of FPR2-G i signaling complex with a peptide agonist. The structure reveals a widely open extracellular region with an amphiphilic environment for ligand binding. Together with computational docking and simulation, the structure suggests a molecular basis for the recognition of formylpeptides and a potential mechanism of receptor activation, and reveals conserved and divergent features in G i coupling. Our results provide a basis for understanding the molecular mechanism ofthe functional promiscuity of FPRs. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280397]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR) 2.Takeda Research 3.Medical College of Georgia, Augusta University 4.Center for Cancer and Cell Biology, Program for Structural Biology, Van Andel Research Institute 5.David Van Andel Advanced Cryo-Electron Microscopy Suite, Van Andel Research Institute 6.University of Pittsburgh 7.The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 8.University of Chinese Academy of Sciences |
| 推荐引用方式 GB/T 7714 | Youwen Zhuang,Heng Liu,X. Edward Zhou,et al. Structure of formylpeptide receptor 2-G i complex reveals insights into ligand recognition and signaling[J]. naturecommunications,2020,11(1):1. |
| APA | Youwen Zhuang.,Heng Liu.,X. Edward Zhou.,Ravi Kumar Verma.,Parker W. de Waal.,...&Cheng Zhang.(2020).Structure of formylpeptide receptor 2-G i complex reveals insights into ligand recognition and signaling.naturecommunications,11(1),1. |
| MLA | Youwen Zhuang,et al."Structure of formylpeptide receptor 2-G i complex reveals insights into ligand recognition and signaling".naturecommunications 11.1(2020):1. |
入库方式： OAI收割
来源：上海药物研究所
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