Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
文献类型：期刊论文
| 作者 | Tao Tan; Haiyan Hu; Hong Wang; Jie Li; Zhiwan Wang; Jing Wang; Siling Wang; Zhiwen Zhang; Yaping Li |
| 刊名 | naturecommunications
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:1页码:1 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-019-11235-4 |
| 英文摘要 | The tumor stromal microenvironments (TSM) including stromal cells and extracellular matrix (ECM) form an abominable barrier hampering nanoparticles accessibility to cancer cells, significantly compromising their antitumor effects. Herein, we report a bioinspired lipoprotein (bLP) that can induce efficient photothermia to remodel TSM and improve second bLP accessibility to cancer cells for antitumor therapy. The multiple stromal cells and ECM components in TSM are remarkably disrupted by bLP-mediated photothermal effects, which cause a 4.27-fold enhancement of second bLP accumulation in tumor, deep penetration in whole tumor mass and 27.0-fold increase of accessibility to cancer cells. Of note, this bLP-mediated TSM-remodeling to enhance cancer cell accessibility (TECA) strategy produces an eminent suppression of tumor growth and results in a 97.4% inhibition of lung metastasis, which is superior to the counterpart liposomes. The bLP-mediated TECA strategy provides deeper insights into enhancing nanoparticle accessibility to cancer cells for antitumor therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000477017600004 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280417]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.Yantai University 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences 3.Shenyang Pharmaceutical University 4.Yantai Institute of Materia Medica |
| 推荐引用方式 GB/T 7714 | Tao Tan,Haiyan Hu,Hong Wang,et al. Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles[J]. naturecommunications,2019,10(1):1. |
| APA | Tao Tan.,Haiyan Hu.,Hong Wang.,Jie Li.,Zhiwan Wang.,...&Yaping Li.(2019).Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles.naturecommunications,10(1),1. |
| MLA | Tao Tan,et al."Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles".naturecommunications 10.1(2019):1. |
入库方式： OAI收割
来源：上海药物研究所
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