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  2. 上海药物研究所
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  4. 新药研究国家重点实验室
Sinulasterols A-C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa

文献类型：期刊论文

作者Yang, Min1,2; Cui, Wan-Xiang1,4; Li, Heng2,3; Li, Song-Wei1,5; Yao, Li-Gong1; Tang, Wei2,3; Mudianta, I. Wayan6; Guo, Yue-Wei1,2
刊名STEROIDS
出版日期2020-05-01
卷号157页码:5
关键词Sinularia Oxygenated steroids Anti-inflammatory
ISSN号0039-128X
DOI10.1016/j.steroids.2020.108598
通讯作者Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Three new oxygenated steroids, sinulasterols A-C (1-3), along with seven known related steroids 4-10, were isolated from the Chinese soft coral Sinularia depressa. The structures of the new compounds were established from extensive spectroscopic data analyses and by comparison of their spectral data with those reported in the literature. Among the new compounds, metabolites 1 and 2 featured on unusual C-18 oxygenated pattern. In the TNF-alpha bioassay, compound 4 exhibited a potent inhibitory activity (IC50 = 12.1 mu M), which was analogous to the positive control dexamethasone (IC50 = 8.7 mu M), metabolites 1 and 2 displayed a moderate inhibitory activity (IC50 51.1 mu M and 22.7 mu M respectively).
WOS关键词POLYHYDROXYLATED STEROIDS ; MARINE-INVERTEBRATES ; METABOLITES
资助项目National Key Research and Development Program of China[2018YFC0310903] ; National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[81520108028] ; National Natural Science Foundation of China[21672230] ; National Natural Science Foundation of China[81603022] ; NSFC/CNRS joint project[81811530284] ; Drug Innovation Major Project[2018ZX09711001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04]
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种英语
WOS记录号WOS:000527364000004
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/280428]  
专题新药研究国家重点实验室
通讯作者Guo, Yue-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Shanghai 201203, Peoples R China
4.Binzhou Med Univ, Sch Pharm, 346 Guanhai Rd, Yantai 264003, Peoples R China
5.Nanjing Univ Chinese Med, Nanjing 210023, Peoples R China
6.Univ Pendidikan Ganesha, Bali 81116, Indonesia
推荐引用方式
GB/T 7714		 Yang, Min,Cui, Wan-Xiang,Li, Heng,et al. Sinulasterols A-C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa[J]. STEROIDS,2020,157:5.
APA Yang, Min.,Cui, Wan-Xiang.,Li, Heng.,Li, Song-Wei.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2020).Sinulasterols A-C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa.STEROIDS,157,5.
MLA Yang, Min,et al."Sinulasterols A-C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa".STEROIDS 157(2020):5.

入库方式： OAI收割

来源：上海药物研究所

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