Metaproteomics: A strategy to study the taxonomy and functionality of the gut microbiota
文献类型：期刊论文
| 作者 | Wang, Yuqiu1,2,3,4; Zhou, Yanting1,2; Xiao, Xiao3; Zheng, Jing3; Zhou, Hu1,2
|
| 刊名 | JOURNAL OF PROTEOMICS
 |
| 出版日期 | 2020-05-15 |
| 卷号 | 219页码:11 |
| 关键词 | Metaproteomics Gut microbiota Metagenomics Metatranscriptomics Metabolomics Multi-omics |
| ISSN号 | 1874-3919 |
| DOI | 10.1016/j.jprot.2020.103737 |
| 通讯作者 | Zheng, Jing(zhengjing@ecust.edu.cn) ; Zhou, Hu(zhouhu@simm.ac.cn) |
| 英文摘要 | The gut microbiota is the largest and most complex microbial community in the human body. Host-gut microbiota interactions have significant implications on health and disease. The development of genome-sequencing technologies, especially the application of next-generation sequencing (NGS), has accelerated the study of the gut microbiota. Most gut microbiota studies rely on 16S rRNA sequencing, metagenomics, and metatranscriptomics, but metaproteomics, based on mass spectrometry (MS), provides functional information on the signaling and metabolic pathways in the gut microbiota. This review is intended to introduce different research methods to study the gut microbiota, with a specific focus on the current progress and application of metaproteomics. Significance: The gut microbiota plays a key role in human health and disease. In this review, different research methods are described and compared in the field of the gut microbiota. Among these research methods, metaproteomics reveals the taxonomy and functionality of the gut microbiota, especially the functional pathways associated with diseases. Thus, the current progress and application of metaproteomics are summarized, in order to enhance a comprehensive depiction of metaproteomics. |
| WOS关键词 | GASTROINTESTINAL MICROBIOME ; MASS-SPECTROMETRY ; HOST GENETICS ; FECAL SAMPLES ; BACTERIA ; IMPACT ; IDENTIFICATION ; METAGENOMICS ; SENSITIVITY ; ENRICHMENT |
| 资助项目 | National Key Research and Development Program from the Ministry of Science and Technology of China[2017YFC1700200] ; Nova Development Program of the Shanghai Institute of Materia Medica |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000527378000005 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280487]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zheng, Jing; Zhou, Hu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, Shanghai 201203, Peoples R China 3.East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 4.East China Univ Sci & Technol, Sch Bioengn, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yuqiu,Zhou, Yanting,Xiao, Xiao,et al. Metaproteomics: A strategy to study the taxonomy and functionality of the gut microbiota[J]. JOURNAL OF PROTEOMICS,2020,219:11. |
| APA | Wang, Yuqiu,Zhou, Yanting,Xiao, Xiao,Zheng, Jing,&Zhou, Hu.(2020).Metaproteomics: A strategy to study the taxonomy and functionality of the gut microbiota.JOURNAL OF PROTEOMICS,219,11. |
| MLA | Wang, Yuqiu,et al."Metaproteomics: A strategy to study the taxonomy and functionality of the gut microbiota".JOURNAL OF PROTEOMICS 219(2020):11. |
入库方式： OAI收割
来源：上海药物研究所
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