Construction of Thiazole-Fused Dihydropyrans via Formal [4+2] Cycloaddition Reaction on DNA
文献类型：期刊论文
| 作者 | Wu, Wenting2; Sun, Zhen2; Wang, Xuan1,2; Lu, Xiaojie1 ; Dai, Dongcheng2
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2020-04-17 |
| 卷号 | 22期号:8页码:3239-3244 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.0c01016 |
| 通讯作者 | Dai, Dongcheng(ddai@amgen.com) |
| 英文摘要 | An efficient and facile formal [4 + 2] cycloaddition reaction was developed to synthesize diverse thiazole-fused dihydropyrans (TFDP) on DNA. Mild reaction conditions, broad substrate scope, and compatibility with subsequent enzymatic ligation demonstrated the utility of this methodology in DNA-encoded library synthesis. |
| WOS关键词 | ENCODED CHEMICAL LIBRARIES ; ANNULATION ; ALDEHYDES ; POTENT |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000526894000075 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280493]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Dai, Dongcheng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Amgen Res, Amgen Asia R&D Ctr, Dept Therapeut Discovery, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Wenting,Sun, Zhen,Wang, Xuan,et al. Construction of Thiazole-Fused Dihydropyrans via Formal [4+2] Cycloaddition Reaction on DNA[J]. ORGANIC LETTERS,2020,22(8):3239-3244. |
| APA | Wu, Wenting,Sun, Zhen,Wang, Xuan,Lu, Xiaojie,&Dai, Dongcheng.(2020).Construction of Thiazole-Fused Dihydropyrans via Formal [4+2] Cycloaddition Reaction on DNA.ORGANIC LETTERS,22(8),3239-3244. |
| MLA | Wu, Wenting,et al."Construction of Thiazole-Fused Dihydropyrans via Formal [4+2] Cycloaddition Reaction on DNA".ORGANIC LETTERS 22.8(2020):3239-3244. |
入库方式： OAI收割
来源：上海药物研究所
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