Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation
文献类型：期刊论文
| 作者 | Deng, Ying-Zhi1,2,3; Lu, Yu-Chen1,2,3; Wu, Wei-Wei1,2,3; Cheng, Li4; Zan, Gui-Ying2,3; Chai, Jing-Rui2,3; Wang, Yu-Jun1,2,3 ; Chen, Zhong4; Liu, Jing-Gen1,2,3,4
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| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2020-05-15 |
| 卷号 | 168页码:9 |
| 关键词 | Anteromedial thalamic nucleus Anterior cingulate cortex Itch Histamine |
| ISSN号 | 0028-3908 |
| DOI | 10.1016/j.neuropharm.2020.108028 |
| 通讯作者 | Wang, Yu-Jun(yjwang@mail.simm.ac.cn) |
| 英文摘要 | Itch is an unpleasant feeling that triggers scratching behavior. Much progress has been made in identifying the mechanism of itch at the peripheral and spinal levels, however, itch circuits in the brain remain largely unexplored. We previously found that anterior cingulate cortex (ACC) to dorsal medial striatum (DMS) inputs modulated histamine-induced itch sensation, but how itch information was transmitted to ACC remained unclear. Here, we demonstrated that the anteromedial thalamic nucleus (AM) was activated during histaminergic itch, and there existed reciprocal neuronal projections between AM and ACC. Disconnection between AM and ACC resulted in a significant reduction of histaminergic, but not nonhistaminergic, itch-related scratching behavior. Optogenetic activation of AM-ACC, but not ACC-AM, projections evoked histaminergic itch sensation. Thus, our studies firstly reveal that AM is critical for histaminergic itch sensation and AM-ACC projections modulate histaminergic itch-induced scratching behavior. |
| WOS关键词 | STATE-DEPENDENT INHIBITION ; TRACT NEURONS ; DORSAL-HORN ; SCRATCH ; ANTIHISTAMINES ; SELECTION ; CIRCUITS ; RELIEF ; CELLS |
| 资助项目 | National Natural Science Foundation of China[81401107] ; National Natural Science Foundation of China[81671322] ; Ministry of Science and Technology of China[2013CB835102] ; Ministry of Science and Technology of China[2015CB553502] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017334] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000528256100004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280541]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Yu-Jun |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, Shanghai 201203, Peoples R China 4.Zhejiang Chinese Med Univ, Hangzhou 310053, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Ying-Zhi,Lu, Yu-Chen,Wu, Wei-Wei,et al. Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation[J]. NEUROPHARMACOLOGY,2020,168:9. |
| APA | Deng, Ying-Zhi.,Lu, Yu-Chen.,Wu, Wei-Wei.,Cheng, Li.,Zan, Gui-Ying.,...&Liu, Jing-Gen.(2020).Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation.NEUROPHARMACOLOGY,168,9. |
| MLA | Deng, Ying-Zhi,et al."Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation".NEUROPHARMACOLOGY 168(2020):9. |
入库方式： OAI收割
来源：上海药物研究所
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