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Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis

文献类型：期刊论文

作者Li, Heng1,2; Feng, Chunlan2; Fan, Chen2; Yang, Yang3; Yang, Xiaoqian2; Lu, Huimin1,2; Lu, Qiukai1,2; Zhu, Fenghua2; Xiang, Caigui1,2; Zhang, Zongwang2
刊名CELL DEATH & DISEASE
出版日期2020-04-24
卷号11期号:4页码:17
ISSN号2041-4889
DOI10.1038/s41419-020-2470-8
通讯作者Zuo, Jianping(jpzuo@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn)
英文摘要Ulcerative colitis (UC) is a chronic and etiologically refractory inflammatory gut disorder. Although berberine, an isoquinoline alkaloid, has been revealed to exert protective effects on experimental colitis, the underlying molecular mechanism in chronic intestinal inflammation remains ill-defined. This study was designed to uncover the therapeutic efficacy and immunomodulatory role of berberine in chronic UC. Therapeutic effects of oral administration of berberine were investigated in dextran sodium sulfate (DSS)-induced murine chronic UC and the underlying mechanisms were further identified by si-OSMR transfection in human intestinal stromal cells. Berberine significantly attenuated the experimental symptoms and gut inflammation of chronic UC. Berberine treatment could also maintain the intestinal barrier function and rectify tissue fibrosis. In accordance with infiltrations of antigen-presenting cells (APCs), innate lymphoid cells (ILCs), and activated NK cells in colonic lamina propria, increased expression of OSM and OSMR were observed in the inflamed tissue of chronic UC, which were decreased following berberine treatment. Moreover, berberine inhibited the overactivation of human intestinal stromal cells through OSM-mediated JAK-STAT pathway, which was obviously blocked upon siRNA targeting OSMR. The research provided an infusive mechanism of berberine and illustrated that OSM and OSMR intervention might function as the potential target in chronic UC.
WOS关键词BOWEL-DISEASE ; INTESTINAL FIBROSIS ; BARRIER FUNCTION ; CLASSIFICATION ; EXPRESSION ; MODELS ; COLON ; MICE
资助项目Science & Technology Commission of Shanghai Municipality, China[18431907100]
WOS研究方向Cell Biology
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000530255700002
源URL[http://119.78.100.183/handle/2S10ELR8/280551]  
专题中国科学院上海药物研究所
通讯作者Zuo, Jianping; Tang, Wei
作者单位1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Heng,Feng, Chunlan,Fan, Chen,et al. Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis[J]. CELL DEATH & DISEASE,2020,11(4):17.
APA Li, Heng.,Feng, Chunlan.,Fan, Chen.,Yang, Yang.,Yang, Xiaoqian.,...&Tang, Wei.(2020).Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis.CELL DEATH & DISEASE,11(4),17.
MLA Li, Heng,et al."Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis".CELL DEATH & DISEASE 11.4(2020):17.

入库方式： OAI收割

来源：上海药物研究所

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