CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment
文献类型：期刊论文
| 作者 | Xing, Hui1,2; Meng, Ling-hua1,2
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2020-05-01 |
| 卷号 | 41期号:5页码:583-587 |
| 关键词 | precision medicine CRISPR-cas9 drug target biomarker drug resistance synergistic lethality |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-019-0322-9 |
| 通讯作者 | Meng, Ling-hua(lhmeng@simm.ac.cn) |
| 英文摘要 | Cancer is a highly heterogeneous disease in term of molecular signature even though it is originated from the same tissue type. Cancer heterogeneity may occur during its development or treatment, which is the main cause resulting in drug resistance and recurrence. Precision medicine refers to matching the right medicine to the right patients based on their molecular signatures. Therefore, a thorough understanding of the mechanism of tumorigenesis and drug resistance is essential to precision medicine. CRISPR-cas9 system is a powerful tool for gene editing and CRISPR-based high-throughput screening has been widely applied especially in searching for tumor-driven or synergistic lethal genes aiming to overcome drug resistance. In this review, we describe the progress of CRISPR-cas9-based unbiased screening in precision medicine including identification of new drug targets, biomarkers and elucidation of mechanisms leading to drug resistance. The existing challenges as well as the future directions are also discussed. |
| WOS关键词 | RNA ; CAS ; DISCOVERY ; SCREENS ; CRISPR/CAS9 ; GENERATION ; EVOLUTION ; TARGETS ; DESIGN ; GUIDE |
| 资助项目 | Chinese Academy of Sciences[XDA12020111] ; National Science and Technology Major Project Key New Drug Creation and Manufacturing Program[2018ZX09711002-011-014] ; National Science and Technology Major Project Key New Drug Creation and Manufacturing Program[2018ZX09711002-004-011] ; National Natural Science Foundation of China[81773760] ; Fudan-SIMM Joint Research Fund[FU-SIMM20172005] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000529703000001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280558]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Meng, Ling-hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, Hui,Meng, Ling-hua. CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment[J]. ACTA PHARMACOLOGICA SINICA,2020,41(5):583-587. |
| APA | Xing, Hui,&Meng, Ling-hua.(2020).CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment.ACTA PHARMACOLOGICA SINICA,41(5),583-587. |
| MLA | Xing, Hui,et al."CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment".ACTA PHARMACOLOGICA SINICA 41.5(2020):583-587. |
入库方式： OAI收割
来源：上海药物研究所
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