trailbasedgenedeliveryandtherapeuticstrategies
文献类型：期刊论文
| 作者 | Zhong Huihai2; Wang Huiyuan1 ; Li Jian2; Huang Yongzhuo1
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2019 |
| 卷号 | 40期号:11页码:1373 |
| 关键词 | APOPTOSIS-INDUCING LIGAND MESENCHYMAL STEM-CELLS PROSTATE-CANCER CELLS DEATH RECEPTOR 5 CO-DELIVERY IN-VIVO MEDIATED APOPTOSIS ANTITUMOR-ACTIVITY TUMORICIDAL ACTIVITY PROTEIN EXPRESSION TRAIL gene delivery gene therapy DNA drug delivery systems non-viral vectors cancer therapy |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-019-0287-8 |
| 英文摘要 | TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), also known as APO2L, belongs to the tumor necrosis factor family. By binding to the death receptor 4 (DR4) or DR5, TRAIL induces apoptosis of tumor cells without causing side toxicity in normal tissues. In recent years TRAIL-based therapy has attracted great attention for its promise of serving as a cancer drug candidate. However, the treatment efficacy of TRAIL protein was under expectation in the clinical trials because of the short half-life and the resistance of cancer cells. TRAIL gene transfection can produce a "bystander effect" of tumor cell killing and provide a potential solution to TRAIL-based cancer therapy. In this review we focus on TRAIL gene therapy and various design strategies of TRAIL DNA delivery including non-viral vectors and cell-based TRAIL therapy. In order to sensitize the tumor cells to TRAIL-induced apoptosis, combination therapy of TRAIL DNA with other drugs by the codelivery methods for yielding a synergistic antitumor efficacy is summarized. The opportunities and challenges of TRAIL-based gene delivery and therapy are discussed. |
| 资助项目 | [973 Program, China] ; [NFSC] ; [Strategic Priority Research Program of CAS] ; [National Special Project for Significant New Drugs Development] ; [CAS Scientific Research and Equipment Development Project] ; [Fudan-SIMM Joint Research Fund] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280688]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.上海大学 |
| 推荐引用方式 GB/T 7714 | Zhong Huihai,Wang Huiyuan,Li Jian,et al. trailbasedgenedeliveryandtherapeuticstrategies[J]. actapharmacologicasinica,2019,40(11):1373. |
| APA | Zhong Huihai,Wang Huiyuan,Li Jian,&Huang Yongzhuo.(2019).trailbasedgenedeliveryandtherapeuticstrategies.actapharmacologicasinica,40(11),1373. |
| MLA | Zhong Huihai,et al."trailbasedgenedeliveryandtherapeuticstrategies".actapharmacologicasinica 40.11(2019):1373. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。