Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol
文献类型：期刊论文
| 作者 | He, Yuanzhi1; Hou, Xuefeng1; Guo, Jingwen1; He, Zehui1; Guo, Teng1; Liu, Ying1; Zhang, Yongtai1; Zhang, Jiwen2,3 ; Feng, Nianping1
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2020-05-01 |
| 卷号 | 235页码:10 |
| ISSN号 | 0144-8617 |
| 关键词 | gamma-cyclodextrin metal-organic framework Activation Honokiol Supercritical carbon dioxide Bioavailability |
| DOI | 10.1016/j.carbpol.2020.115935 |
| 通讯作者 | Feng, Nianping(npfeng@hotmail.com) |
| 英文摘要 | A facile method for the activation of gamma-cyclodextrin metal-organic framework (CD-MOF) without channel blockage and framework collapse was first developed using supercritical carbon dioxide (scCO(2)), which enabled higher surface area and larger pore volume. The scCO(2)-assisted impregnation method was also applied to introduce the insoluble drug, honokiol (HNK), into the pores of CD-MOF with higher cargo loading compared to the conventional liquid phase incorporation in ethanol. Notably, the resulting HNK-loaded CD-MOF (HNK@CD-MOF) had improved apparent solubility and enhanced dissolution rate. The intestinal cellular uptake and transport experiments demonstrated that CD-MOF could enhance cellular uptake and increase drug transport across the intestinal epithelial cells compared to the cyclodextrin inclusion complex. Moreover, the in vivo pharmacokinetic studies further confirmed that CD-MOF could significantly improve the oral absorption and bioavailability of HNK. Overall, the scCO(2) activation and scCO(2)-assisted impregnation approaches were demonstrated as promising strategies to maximize the potential capability of CD-MOF. |
| WOS关键词 | INCREASED ORAL BIOAVAILABILITY ; CD-MOF ; INCLUSION COMPLEX ; DRUG-DELIVERY ; NANOPARTICLES ; ENCAPSULATION ; PHARMACOKINETICS ; STABILITY ; ENHANCEMENT ; SOLUBILITY |
| 资助项目 | National Natural Science Foundation of China[81573619] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000519044900009 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280840]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Feng, Nianping |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept Pharmaceut Sci, Shanghai 201203, Peoples R China 2.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Yuanzhi,Hou, Xuefeng,Guo, Jingwen,et al. Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol[J]. CARBOHYDRATE POLYMERS,2020,235:10. |
| APA | He, Yuanzhi.,Hou, Xuefeng.,Guo, Jingwen.,He, Zehui.,Guo, Teng.,...&Feng, Nianping.(2020).Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol.CARBOHYDRATE POLYMERS,235,10. |
| MLA | He, Yuanzhi,et al."Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol".CARBOHYDRATE POLYMERS 235(2020):10. |
入库方式： OAI收割
来源：上海药物研究所
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