Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk-Shell Structure Augment Cancer Chemotherapy
文献类型：期刊论文
| 作者 | Nie, Di2,4; Dai, Zhuo2,5; Li, Jialin2,5; Yang, Yiwei2,4; Xi, Ziyue1,2; Wang, Jie1,2; Zhang, Wei1,2; Qian, Kun2,4; Guo, Shiyan2; Zhu, Chunliu2
|
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2020-02-01 |
| 卷号 | 20期号:2页码:936-946 |
| ISSN号 | 1530-6984 |
| 关键词 | cancer cell membrane coating yolk-shell structure tumor penetration membrane fusion intracellular trafficking perinuclear aggregation |
| DOI | 10.1021/acs.nanolett.9b03817 |
| 通讯作者 | Gan, Yong(ygan@simm.ac.cn) |
| 英文摘要 | Despite rapid advancements in antitumor drug delivery, insufficient intracellular transport and subcellular drug accumulation are still issues to be addressed. Cancer cell membrane (CCM)-camouflaged nanoparticles (NPs) have shown promising potential in tumor therapy due to their immune escape and homotypic binding capacities. However, their efficacy is still limited due to inefficient tumor penetration and compromised intracellular transportation. Herein, a yolk-shell NP with a mesoporous silica nanoparticle (MSN)supported PEGylated liposome yolk and CCM coating, CCM@LM, was developed for chemotherapy and exhibited a homologous tumor-targeting effect. The yolk-shell structure endowed CCM@LM with moderate rigidity, which might contribute to the frequent transformation into an ellipsoidal shape during infiltration, leading to facilitated penetration throughout multicellular spheroids in vitro (up to a 23.3-fold increase compared to the penetration of membrane vesicles). CCM@LM also exhibited a cellular invasion profile mimicking an enveloped virus invasion profile. CCM@LM was directly internalized by membrane fusion, and the PEGylated yolk (LM) was subsequently released into the cytosol, indicating the execution of an internalization pathway similar to that of an enveloped virus. The incoming PEGylated LM further underwent efficient trafficking throughout the cytoskeletal filament network, leading to enhanced perinuclear aggregation. Ultimately, CCM@LM, which co-encapsulated low-dose doxorubicin and the poly(ADP-ribose) polymerase inhibitor, mefuparib hydrochloride, exhibited a significantly stronger antitumor effect than the first-line chemotherapeutic drug Doxil. Our findings highlight that NPs that can undergo facilitated tumor penetration and robust intracellular trafficking have a promising future in cancer chemotherapy. |
| WOS关键词 | NUCLEAR-MEMBRANE ; VIRUS ENTRY ; DELIVERY ; PLATFORM ; FUSION ; LIPOSOMES ; THERAPY |
| 资助项目 | National Natural Science Foundation of China[81803445] ; National Natural Science Foundation of China[81573378] ; National Natural Science Foundation of China[81773651] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA12050307] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA12020222] ; Shanghai Scientific and Technology Innovation Plan, Shanghai Science and Technology Committee[18430721600] ; K.C. Wong Education Foundation ; New Star Program, Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000514255400016 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280853]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Nanosyst & Hierarchy Fabricat, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nie, Di,Dai, Zhuo,Li, Jialin,et al. Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk-Shell Structure Augment Cancer Chemotherapy[J]. NANO LETTERS,2020,20(2):936-946. |
| APA | Nie, Di.,Dai, Zhuo.,Li, Jialin.,Yang, Yiwei.,Xi, Ziyue.,...&Gan, Yong.(2020).Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk-Shell Structure Augment Cancer Chemotherapy.NANO LETTERS,20(2),936-946. |
| MLA | Nie, Di,et al."Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk-Shell Structure Augment Cancer Chemotherapy".NANO LETTERS 20.2(2020):936-946. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。