中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Macrophage-based nanotherapeutic strategies in ulcerative colitis

文献类型：期刊论文

作者Zhang, Jiaxin3,4; Zhao, Yuge4,5; Hou, Tianling6; Zeng, Hairong7; Kalambhe, Dipika2,4; Wang, Bing3,4; Shen, Xiaoyan1; Huang, Yongzhuo2,4
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2020-04-10
卷号320页码:363-380
关键词Ulcerative colitis Macrophage Drug delivery system Inflammation Nanomedicine
ISSN号0168-3659
DOI10.1016/j.jconrel.2020.01.047
通讯作者Wang, Bing(bwang@simm.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Macrophages, an important component of the innate immune response, are a key regulator of intestinal microenvironment homeostasis. These cells essentially contribute to chronic inflammatory diseases due to their strong plasticity. As is known, ulcerative colitis (UC), a chronic inflammatory disease, is closely related to immune dysfunction. A growing body of evidence suggests that the macrophage is a promising drug target for modulating the intestinal immune systems and regulating the inflammatory microenvironment, thus alleviating the inflammatory responses in UC. The macrophage-based therapy strategies for UC are still at an emerging stage. The advanced drug delivery systems can improve the macrophage-based therapy. This article will review the molecular mechanisms related to macrophage polarization and the interactions between signaling pathways that regulate the pathogenesis of UC and summarize the macrophage-based nanotherapeutic strategies in UC.
WOS关键词NF-KAPPA-B ; ACTIVATED PROTEIN-KINASE ; INFLAMMATORY-BOWEL-DISEASE ; SODIUM-INDUCED COLITIS ; TNBS-INDUCED COLITIS ; PROINFLAMMATORY CYTOKINES ; ANTIINFLAMMATORY ACTION ; INTESTINAL MACROPHAGES ; COLONIC MACROPHAGES ; CELL-PROLIFERATION
资助项目Program of Shanghai Committee of Science and Technology, China[17401902300] ; NFSC[81925035] ; NFSC[81673382] ; NFSC[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant New Drugs Development[2018ZX09711002-010-002] ; CAS Scientific Research and Equipment Development Project[YZ201437] ; Fudan-SIMM Joint Research Fund[FU-SIMM20174009]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000522794800030
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/280879]  
专题新药研究国家重点实验室
通讯作者Wang, Bing; Huang, Yongzhuo
作者单位1.Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
5.Nanchang Univ, Sch Pharm, Nanchang, Jiangxi, Peoples R China
6.Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA
7.Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Pharm, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Jiaxin,Zhao, Yuge,Hou, Tianling,et al. Macrophage-based nanotherapeutic strategies in ulcerative colitis[J]. JOURNAL OF CONTROLLED RELEASE,2020,320:363-380.
APA Zhang, Jiaxin.,Zhao, Yuge.,Hou, Tianling.,Zeng, Hairong.,Kalambhe, Dipika.,...&Huang, Yongzhuo.(2020).Macrophage-based nanotherapeutic strategies in ulcerative colitis.JOURNAL OF CONTROLLED RELEASE,320,363-380.
MLA Zhang, Jiaxin,et al."Macrophage-based nanotherapeutic strategies in ulcerative colitis".JOURNAL OF CONTROLLED RELEASE 320(2020):363-380.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。