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Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum

文献类型：期刊论文

作者Yang, Fan1,3,4,5; Li, Song-Wei1; Zhang, Jun3; Liang, Lin-Fu1,2; Lu, Yan-Hua4,5; Guo, Yue-Wei1
刊名BIOORGANIC CHEMISTRY
出版日期2020-03-01
卷号96页码:8
关键词Litophyton nigrum Nornardosinane Seconeolemnane Cytotoxicity Inhibitory activity
ISSN号0045-2068
DOI10.1016/j.bioorg.2020.103636
通讯作者Liang, Lin-Fu(lianglinfu@aliyun.com) ; Lu, Yan-Hua(luyanhua@ecust.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Three new nardosinane-type sesquiterpenoids linardosinenes A-C (1-3) and four new neolemnane-type sesquiterpenoids lineolemnenes A-D (4-7), together with the related known compound 4-acetoxy-2,8-neolemnadien-5-one (8), were isolated from the Xisha soft coral Litophyton nigrum. The structures of these new compounds were elucidated by comprehensive analyses of spectroscopic data, in association with modified Mosher's method and ECD calculations for configurational assignments and the absolute configuration of 8 was determined by X-ray diffraction analysis for the first time. Structurally uncommon nornardosinane and seconeolemnane skeletons for compounds 1 and 7, respectively, are rare carbon frameworks in naturally occurring sesquiterpenoids. The absolute configurations of 1, 7, and 8 were determined by modified Mosher's method, TDDFT ECD approach, and X-ray diffraction analysis, respectively. This is the first chemical study of L. nigrum and the first report of nornardosinane, seconeolemnane and related sesquiterpenoids from the genus Litophyton. The isolates 1-7 were evaluated for their cytotoxicity against THP-1, SNU-398, HT-29, Capan-1 and A549 cell lines and inhibitory activities against PTP1B, BRD4, HDAC1 and HDAC6 protein kinases. The results indicated that compounds 2-5 inhibited proliferation of human cancer cells. However, none of them were potent inhibitors of protein kinases.
WOS关键词NORSESQUITERPENOIDS ; GROWTH
资助项目National Natural Science Foundation of China, China[81991521] ; National Natural Science Foundation of China, China[81520108028] ; National Natural Science Foundation of China, China[21672230] ; National Natural Science Foundation of China, China[41876194] ; National Natural Science Foundation of China, China[41876189] ; National Natural Science Foundation of China, China[81603022] ; National Key Research and Development Program of China, China[2018YFC0310903] ; National Key Research and Development Program of China, China[2018YFC1706200] ; Drug Innovation Major Project, China[2018ZX09711-001-001-009] ; SKLDR/SIMM, China Projects[SIMM1903ZZ-04]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000516796900076
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/280963]  
专题新药研究国家重点实验室
通讯作者Liang, Lin-Fu; Lu, Yan-Hua; Guo, Yue-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
2.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
3.Shanghai Normal Univ, Coll Life & Environm Sci, Biol Dept, 100 Guilin Rd, Shanghai 200234, Peoples R China
4.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China
5.Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Fan,Li, Song-Wei,Zhang, Jun,et al. Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum[J]. BIOORGANIC CHEMISTRY,2020,96:8.
APA Yang, Fan,Li, Song-Wei,Zhang, Jun,Liang, Lin-Fu,Lu, Yan-Hua,&Guo, Yue-Wei.(2020).Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum.BIOORGANIC CHEMISTRY,96,8.
MLA Yang, Fan,et al."Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum".BIOORGANIC CHEMISTRY 96(2020):8.

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来源：上海药物研究所

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