Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic
文献类型：期刊论文
| 作者 | Sun, Tao1,2; Zhang, Guangping3,4; Guo, Zhongyuan1,2; Chen, Qinjun1,2; Zhang, Yujie1,2; Chu, Yongchao1,2; Guo, Qin1,2; Li, Chao1,2; Zhou, Wenxi1,2; Zhang, Yiwen1,2 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2020-05-10 |
| 卷号 | 321页码:483-496 |
| 关键词 | Cu chelator Antiangiogenesis Theranostic Real-time reporting Co-delivery |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2020.02.023 |
| 通讯作者 | Jiang, Chen(jiangchen@shmu.edu.cn) |
| 英文摘要 | Chelating Cu from tumors has been verified as an effective and promising strategy for cancer therapy through antiangiogenesis. However, systematic removal Cu by injecting with Cu chelators will result unavoidable side effects, since Cu is indispensable to the body. In this work, a micelle targeting to tumors' newborn vessels based on a polypeptide was developed to co-load DOX and Probe X, which can go through an "OFF-to-ON" procedure to report the Cu+-capture events in vivo in a real-time way by giving near infrared (NIR) fluorescence and photoacoustic signal. By co-delivering antiangiogenesis and chemotherapeutic reagents, the tumor can be significantly suppressed, meanwhile with a low systematic toxicity. Hopefully, this work can offer new insights in designing sophisticated antitumor strategy. |
| WOS关键词 | COPPER TRAFFICKING ; TARGETING COPPER ; WILSON-DISEASE ; IN-VIVO ; CANCER ; TETRATHIOMOLYBDATE ; COMPLEXES ; THERAPY ; GENE ; NANOPARTICLES |
| 资助项目 | National Natural Science Foundation of China[81872808] ; Program of Shanghai Academic Research Leader[18XD1400500] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX01] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182006] ; Scientific Research Program of Shanghai Health and Family Planning Commission[20184Y0149] ; ZJLab |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000526179100032 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281013]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Jiang, Chen |
| 作者单位 | 1.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Minhang Hosp,State Key Lab Med Neurobiol, Shanghai 201203, Peoples R China 2.Fudan Univ, MOE Frontiers Ctr Brain Sci, Inst Brain Sci, Dept Pharmaceut,Sch Pharm,Res Ctr Aging & Med, Shanghai 201203, Peoples R China 3.Shandong Normal Univ, Sch Phys & Elect, Shandong Prov Key Lab Med Phys & Image Proc Techn, 1 Univ Rd, Jinan 250358, Peoples R China 4.Shandong Normal Univ, Inst Mat & Clean, 1 Univ Rd, Jinan 250358, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 7.Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200438, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Tao,Zhang, Guangping,Guo, Zhongyuan,et al. Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic[J]. JOURNAL OF CONTROLLED RELEASE,2020,321:483-496. |
| APA | Sun, Tao.,Zhang, Guangping.,Guo, Zhongyuan.,Chen, Qinjun.,Zhang, Yujie.,...&Jiang, Chen.(2020).Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic.JOURNAL OF CONTROLLED RELEASE,321,483-496. |
| MLA | Sun, Tao,et al."Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic".JOURNAL OF CONTROLLED RELEASE 321(2020):483-496. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。