Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats
文献类型：期刊论文
| 作者 | Gu, Pan1; Xu, Zi-Hao1; Cao, Yu-Ze1; Liao, Sheng-Hui2; Deng, Qian-Fang1; Yin, Xian-Zhen3; Wang, Zhuo-Lu4; Chen, Zhuo-Hui1; Hu, Xin-Hang1; Wang, Hui1 |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2020-04-01 |
| 卷号 | 36期号:4页码:333-345 |
| 关键词 | Epilepsy Synchrotron radiation 3D Angioarchitecture Blood vessel Remodeling |
| ISSN号 | 1673-7067 |
| DOI | 10.1007/s12264-019-00450-0 |
| 通讯作者 | Xiao, Bo(csuxiaobo123456@163.com) ; Zhang, Meng-Qi(zhangmengqi8912@163.com) |
| 英文摘要 | Characterizing the three-dimensional (3D) morphological alterations of microvessels under both normal and seizure conditions is crucial for a better understanding of epilepsy. However, conventional imaging techniques cannot detect microvessels on micron/sub-micron scales without angiography. In this study, synchrotron radiation (SR)-based X-ray in-line phase-contrast imaging (ILPCI) and quantitative 3D characterization were used to acquire high-resolution, high-contrast images of rat brain tissue under both normal and seizure conditions. The number of blood microvessels was markedly increased on days 1 and 14, but decreased on day 60 after seizures. The surface area, diameter distribution, mean tortuosity, and number of bifurcations and network segments also showed similar trends. These pathological changes were confirmed by histological tests. Thus, SR-based ILPCI provides systematic and detailed views of cerebrovascular anatomy at the micron level without using contrast-enhancing agents. This holds considerable promise for better diagnosis and understanding of the pathogenesis and development of epilepsy. |
| WOS关键词 | GROWTH-FACTOR ; BRAIN ; SEIZURE ; ANGIOGENESIS ; NETWORK ; CANCER ; CELLS ; PROGRESSION ; ASSOCIATION ; TOMOGRAPHY |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000524876000002 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281036]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xiao, Bo; Zhang, Meng-Qi |
| 作者单位 | 1.Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Peoples R China 2.Cent South Univ, Sch Informat Sci & Engn, Changsha 410008, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Hunan Prov Maternal & Child Hlth Care Hosp, Dept Breast Surg, Changsha 410008, Peoples R China 5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Pan,Xu, Zi-Hao,Cao, Yu-Ze,et al. Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats[J]. NEUROSCIENCE BULLETIN,2020,36(4):333-345. |
| APA | Gu, Pan.,Xu, Zi-Hao.,Cao, Yu-Ze.,Liao, Sheng-Hui.,Deng, Qian-Fang.,...&Zhang, Meng-Qi.(2020).Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats.NEUROSCIENCE BULLETIN,36(4),333-345. |
| MLA | Gu, Pan,et al."Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats".NEUROSCIENCE BULLETIN 36.4(2020):333-345. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。