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Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature

文献类型：期刊论文

作者Yi, Xing2; Cao, Ya-Fang1; Wang, Xing3,4; Xu, Hui3; Ban, Shu-Rong2; Dai, Hui-Xiong3,4
刊名TETRAHEDRON LETTERS
出版日期2020-04-16
卷号61期号:16页码:4
关键词Fluoroacylation Arylboronic acid Cross coupling Late-stage diversification of drugs
ISSN号0040-4039
DOI10.1016/j.tetlet.2020.151780
通讯作者Xu, Hui(xuhui2018@simm.ac.cn) ; Ban, Shu-Rong(shurongban@sxmu.edu.cn) ; Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要A palladium-catalyzed fluoroacylation of (hetero)aryl boronic acid with the fluorothioacetates is described at ambient temperature. A variety of aryl, and heteroaryl boronic acids are compatible in the reaction, affording the corresponding fluoroalkyl ketones in moderate to good yields. Further late-stage di-, and trifluoroacylation of drug molecule clofibrate and estrone demonstrated the synthetic practicability of this protocol.2009 Elsevier Ltd. All rights reserved. (C) 2020 Elsevier Ltd. All rights reserved.
WOS关键词COPPER-MEDIATED TRIFLUOROACETYLATION ; ARYL BORONIC ACIDS ; TRIFLUOROMETHYL KETONES ; ALPHA,ALPHA-DIFLUORO KETONES ; DIFLUOROMETHYL KETONES ; EFFICIENT SYNTHESIS ; INHIBITORS ; OXIDATION ; CARBONYLATION ; BROMIDES
资助项目Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; NSFC[21772211] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Program of Shanghai Academic Research Leader[19XD1424600] ; Primary Research & Developement Plan of Shanxi Province[201903D321110] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000527104000011
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/281066]  
专题中国科学院上海药物研究所
通讯作者Xu, Hui; Ban, Shu-Rong; Dai, Hui-Xiong
作者单位1.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China
2.Shanxi Med Univ, Sch Pharmaceut Sci, 56 Xinjian South Rd, Taiyuan 030001, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yi, Xing,Cao, Ya-Fang,Wang, Xing,et al. Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature[J]. TETRAHEDRON LETTERS,2020,61(16):4.
APA Yi, Xing,Cao, Ya-Fang,Wang, Xing,Xu, Hui,Ban, Shu-Rong,&Dai, Hui-Xiong.(2020).Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature.TETRAHEDRON LETTERS,61(16),4.
MLA Yi, Xing,et al."Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature".TETRAHEDRON LETTERS 61.16(2020):4.

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来源：上海药物研究所

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