Intestinal microbes derived butyrate is related to the immunomodulatory activities of Dendrobium officinale polysaccharide
文献类型：期刊论文
| 作者 | Li, Meixia1; Yue, Han1; Wang, Yeqing1; Guo, Ciliang1; Du, Zhenyun1; Jin, Can2; Ding, Kan1
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2020-04-15 |
| 卷号 | 149页码:717-723 |
| 关键词 | Dendrobium officinale Polysaccharide Gut microbiota Metagenomics sequencing SCFAs |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2020.01.305 |
| 通讯作者 | Ding, Kan(dingkan@simm.ac.cn) |
| 英文摘要 | Although immunomodulatory activities of Dendrobium officinale polysaccharide has been investigated for many years, yet the potential contribution of its metabolite derived from intestinal microbes on immunoregulation effect has not been reported. In this study, polysaccharide DOW-5B with average molecular weight of 39.4 kDa was isolated from the stem of Dendrobium officinale Kimura et Migo. The carbohydrate content was 91.97% and no protein was detected. The monosaccharide analysis showed this polysaccharide was composed of glucuronic acid and glucose at a molar ratio (M/G) of 1.2:19.4. Animal test indicated DOW-5B increased the diversity of gut microbiota on mice. Beneficial microbes such as Ruminococcus, Eubacterium, Clostridium, Bifidobacterium, Parabacteroides and Akkermansia muciniphila increased while harmful bacteria in Proteobacteria decreased. Surprisingly, DOW-5B promoted gut microbes to generate more butyrate and mainly produced by Parabacteroides_sp_HGS0025. Further, we found the health of large intestine as well as immunity response of mice was improved. In addition, Parabacteroides_sp_HG50025 positively correlated with butyrate, IgM, IL-10, and INF-alpha products in intestine and mice blood, respectively. The data suggested that Dendrobium officinale polysaccharide has function on immunity may be mediated by butyrate. It adds new evidence to support the basis of how herbal polysaccharides affect immunity. (C) 2020 Elsevier B.V. All rights reserved. |
| WOS关键词 | CHAIN FATTY-ACIDS ; DIETARY FIBER ; BACTERIA ; DIVERSITY ; METABOLISM ; PHYSIOLOGY ; STEM |
| 资助项目 | New Drug Creation and Manufacturing Program, Ministry of Science and Technology, the People Republic of China[2019ZX09735001] ; National Natural Science Foundation of China[31800673] ; National Natural Science Foundation of China[31670814] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000525795400071 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281113]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Meixia,Yue, Han,Wang, Yeqing,et al. Intestinal microbes derived butyrate is related to the immunomodulatory activities of Dendrobium officinale polysaccharide[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,149:717-723. |
| APA | Li, Meixia.,Yue, Han.,Wang, Yeqing.,Guo, Ciliang.,Du, Zhenyun.,...&Ding, Kan.(2020).Intestinal microbes derived butyrate is related to the immunomodulatory activities of Dendrobium officinale polysaccharide.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,149,717-723. |
| MLA | Li, Meixia,et al."Intestinal microbes derived butyrate is related to the immunomodulatory activities of Dendrobium officinale polysaccharide".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 149(2020):717-723. |
入库方式： OAI收割
来源：上海药物研究所
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