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Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer

文献类型：期刊论文

作者Qin, Yuanyuan2,3,4; Chen, Weilong2,3,4; Jiang, Guojuan2,3; Zhou, Lei2,3,4; Yang, Xiaoli2,3; Li, Hongqi5,6; He, Xueyan2,3; Wang, Han-lin1,7; Zhou, Yu-bo7; Huang, Shenglin2,3
刊名SCIENCE ADVANCES
出版日期2020-02-01
卷号6期号:8页码:13
ISSN号2375-2548
DOI10.1126/sciadv.aaw9960
通讯作者Liu, Suling(suling@fudan.edu.cn)
英文摘要Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, little is known about the regulatory mechanisms of MSN in TNBC. We found that MSN significantly stimulated breast cancer cell proliferation and invasion in vitro and tumor growth in vivo, requiring the phosphorylation of MSN and a nucleoprotein NONO-assisted nuclear localization of phosphorylated MSN with protein kinase C (PKC) and then the phosphoryl-ation activation of CREB signaling by PKC. Our study also demonstrated that targeting MSN, NONO, or CREB significantly inhibited breast tumor growth in vivo. These results introduce a new understanding of MSN function in breast cancer and provide favorable evidence that MSN or its downstream molecules might serve as new targets for TNBC treatment.
WOS关键词ERM PROTEINS ; MOESIN ; METASTASIS ; DISEASE ; PHOSPHORYLATION ; PROLIFERATION ; PROGRESSION ; STATISTICS ; EXPRESSION ; INVASION
资助项目National Key Research and Development Program of China (Stem Cell and Translational Research)[2016YFA0101202] ; MOST grant[2015CB553800] ; NSFC[81772799] ; NSFC[81530075] ; NSFC[81930075] ; Program for Outstanding Medical Academic Leader[2019LJ04] ; Fudan-SIMM Joint Research Fund[FU-SIMM20172007] ; Fudan University Research Foundation[IDH 1340042] ; Research Foundation of the Fudan University Shanghai Cancer Center[YJRC1603]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000514842000004
出版者AMER ASSOC ADVANCEMENT SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/281243]  
专题新药研究国家重点实验室
通讯作者Liu, Suling
作者单位1.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
2.Fudan Univ, Shanghai Canc Ctr, Shanghai Med Coll,Canc Inst, Key Lab Breast Canc Shanghai,Innovat Ctr Cell Sig, Shanghai 200032, Peoples R China
3.Fudan Univ, Inst Biomed Sci, Shanghai Med Coll,Canc Inst, Key Lab Breast Canc Shanghai,Innovat Ctr Cell Sig, Shanghai 200032, Peoples R China
4.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Innate Immun & Chron Dis, Hefei 230027, Anhui, Peoples R China
5.Fudan Univ, Zhongshan Hosp, Endoscopy Ctr, Shanghai, Peoples R China
6.Fudan Univ, Zhongshan Hosp, Endoscopy Res Inst, Shanghai, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Qin, Yuanyuan,Chen, Weilong,Jiang, Guojuan,et al. Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer[J]. SCIENCE ADVANCES,2020,6(8):13.
APA Qin, Yuanyuan.,Chen, Weilong.,Jiang, Guojuan.,Zhou, Lei.,Yang, Xiaoli.,...&Liu, Suling.(2020).Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer.SCIENCE ADVANCES,6(8),13.
MLA Qin, Yuanyuan,et al."Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer".SCIENCE ADVANCES 6.8(2020):13.

入库方式： OAI收割

来源：上海药物研究所

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