Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions
文献类型：期刊论文
| 作者 | Li, Heng1,2; Fan, Chen2; Lu, Huimin1,2; Feng, Chunlan2; He, Peilan2; Yang, Xiaoqian2; Xiang, Caigui1,2; Zuo, Jianping1,2,3 ; Tang, Wei1,2
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| 刊名 | ACTA PHARMACEUTICA SINICA B
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| 出版日期 | 2020-03-01 |
| 卷号 | 10期号:3页码:447-461 |
| ISSN号 | 2211-3835 |
| 关键词 | Ulcerative colitis Berberine Mucosal inflammation Enteric glial cells Enteric nervous system |
| DOI | 10.1016/j.apsb.2019.08.006 |
| 通讯作者 | Zuo, Jianping(jpzuo@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn) |
| 英文摘要 | Ulcerative colitis (UC) manifests as an etiologically complicated and relapsing gastrointestinal disease. The enteric nervous system (ENS) plays a pivotal role in rectifying and orchestrating the inflammatory responses in gut tract. Berberine, an isoquinoline alkaloid, is known as its anti-inflammatory and therapeutic effects in experimental colitis. However, little research focused on its regulatory function on ENS. Therefore, we set out to explore the pathological role of neurogenic inflammation in UC and the modulating effects of berberine on neuroeimmune interactions. Functional defects of enteric glial cells (EGCs), with decreased glial fibrillary acidic protein (GFAP) and increased substance P expression, were observed in DSS-induced murine UC. Administration of berberine can obviously ameliorate the disease severity and restore the mucosal barrier homeostasis of UC, closely accompanying by maintaining the residence of EGCs and attenuating inflammatory infiltrations and immune cells over-activation. In vitro, berberine showed direct protective effects on monoculture of EGCs, bone marrow-derived dendritic cells (BMDCs), T cells, and intestinal epithelial cells (IECs) in the simulated inflammatory conditions. Furthermore, berberine could modulate gut EGCs-IECs-immune cell interactions in the co-culture systems. In summary, our study indicated the EGCs-IECs-immune cell interactions might function as a crucial paradigm in mucosal inflammation and provided an infusive mechanism of berberine in regulating enteric neurogenic inflammation. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. |
| WOS关键词 | SULFATE-INDUCED COLITIS ; TNBS-INDUCED COLITIS ; CHAIN FATTY-ACIDS ; INFLAMMATORY RESPONSES ; BARRIER FUNCTION ; SUBSTANCE-P ; MODELS |
| 资助项目 | Science and Technology Commission of Shanghai Municipality, China[18431907100] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| WOS记录号 | WOS:000518042300005 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281291]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zuo, Jianping; Tang, Wei |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Heng,Fan, Chen,Lu, Huimin,et al. Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions[J]. ACTA PHARMACEUTICA SINICA B,2020,10(3):447-461. |
| APA | Li, Heng.,Fan, Chen.,Lu, Huimin.,Feng, Chunlan.,He, Peilan.,...&Tang, Wei.(2020).Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions.ACTA PHARMACEUTICA SINICA B,10(3),447-461. |
| MLA | Li, Heng,et al."Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions".ACTA PHARMACEUTICA SINICA B 10.3(2020):447-461. |
入库方式： OAI收割
来源：上海药物研究所
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