Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model
文献类型：期刊论文
| 作者 | Wang, Tengteng1,2; Jia, Qingyun3; Chen, Tao1,2,4; Yin, Hao5; Tian, Xiaoting5; Lin, Xi6; Liu, Yang1,2,4; Zhao, Yongjian1,2,4; Wang, Yongjun1,2,4; Shi, Qi1,2,4 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2020-02-14 |
| 卷号 | 11页码:17 |
| ISSN号 | 1663-9812 |
| 关键词 | Juanbi-Tang rheumatoid arthritis collagen-induced arthritis synoviocyte tumor necrosis factor |
| DOI | 10.3389/fphar.2020.00045 |
| 通讯作者 | Xu, Hao(hoxu@163.com) ; Liang, Qianqian(liangqianqiantcm@126.com) |
| 英文摘要 | Rheumatoid arthritis (RA) is a chronic autoimmune disease that is primarily characterized by synovial inflammation. In this study, we found that a traditional Chinese decoction, Juanbi-Tang (JBT), JBT attenuated the symptoms of collagen-induced arthritis (CIA) mice and in tumor necrosis factor transgenic (TNF-Tg) mice by attenuating the arthritis index and hind paw thickness. According to histopathological staining of ankle sections, JBT significantly decreased the area of inflammation and reduced bone destruction of ankle joints in both these two types of mice. Moreover, decreased tartaric acid phosphatase-positive osteoclasts were observed in the JBT group compared with those found in the control group. We also revealed that JBT suppressed monocytes and T cells as well as the production of CCL2, CCR6, and CXCR3 ligands. We next used high-performance liquid chromatography to investigate the components and pharmacological properties of this classical herbal medicine in traditional Chinese medicine. Based on network pharmacology, we performed computational prediction simulation of the potential targets of JBT, which indicated the NF-kappa B pathway as its target, which was confirmed in vitro. JBT suppressed the production of pro-inflammatory cytokines including interleukin-6 (IL-6) and IL-8, and inhibited the expression of matrix metalloproteinase 1 in fibroblast-like synoviocytes derived from RA patients (MH7A cells). Furthermore, JBT also suppressed the phosphorylation of p38, JNK, and p65 in TNF-alpha-treated MH7A cells. In summary, this study proved that JBT could inhibit synovial inflammation and bone destruction, possibly by blocking the phosphorylation of NF-kappa B pathway-mediated production of proinflammatory effectors. |
| WOS关键词 | NF-KAPPA-B ; TUMOR-NECROSIS-FACTOR ; RHEUMATOID-ARTHRITIS ; MOUSE MODEL ; ACID ; TARGET ; CELLS |
| 资助项目 | National Natural Science Foundation[81822050] ; National Natural Science Foundation[81920108032] ; National Natural Science Foundation[81673990] ; National Natural Science Foundation[81873321] ; Leading Medical Talents in Shanghai[2019LJ02] ; Dawn Plan of Shanghai Municipal Education Commission[19SG39] ; Program for Innovative Research Team of the Ministry of Science and Technology of China[2015RA4002] ; Research Project of Shanghai Science and Technology Commission[17401971100] ; Shanghai TCM Medical Center of Chronic Disease[2017ZZ01010] ; Innovation Team development projects[IRT1270] ; Three Years Action to Accelerate the Development of Traditional Chinese Medicine Plan[ZY(2018-2020)-CCCX3003] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000517502900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281381]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xu, Hao; Liang, Qianqian |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Inst Spine, Shanghai, Peoples R China 3.Linyi Peoples Hosp, Trauma Surg Dept, Ward 2, Linyi, Shandong, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Key Lab Theory & Therapy Muscles & Bones, Minist Educ, Shanghai, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 6.Univ Rochester, Dept Pathol & Lab Med, Rochester, NY USA |
| 推荐引用方式 GB/T 7714 | Wang, Tengteng,Jia, Qingyun,Chen, Tao,et al. Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model[J]. FRONTIERS IN PHARMACOLOGY,2020,11:17. |
| APA | Wang, Tengteng.,Jia, Qingyun.,Chen, Tao.,Yin, Hao.,Tian, Xiaoting.,...&Liang, Qianqian.(2020).Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model.FRONTIERS IN PHARMACOLOGY,11,17. |
| MLA | Wang, Tengteng,et al."Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model".FRONTIERS IN PHARMACOLOGY 11(2020):17. |
入库方式： OAI收割
来源：上海药物研究所
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