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Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis

文献类型：期刊论文

作者Ye, Miao1,2; Xu, Wen1,2; He, Qing1,2; Wu, Xian1,2; Lai, Wen-Fang1,2; Zhang, Xiao-Qin1,2; Lin, Yu1,2; Xu, Wei1,2; Li, Xu-Wen1,2,3
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2020-02-01
卷号83期号:2页码:362-373
ISSN号0163-3864
DOI10.1021/acs.jnatprod.9b00857
通讯作者Xu, Wei(2000017@fjtcm.edu.cn) ; Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要Eight new dammarane-type triterpenoids (1-8), together with a related known analogue (9), were isolated from the roots of Rhus chinensis, a traditional Chinese medicine for treating coronary artery heart disease, guided by LC-MS analysis. Their structures were elucidated based on extensive spectroscopic analysis and quantum chemical calculations. Notably, compounds 1-7 and 9 possess an unusual 17 alpha-side chain, and 1-4, 6, and 9 contain an uncommon 3-methyl-5,6-dihydro-2H-pyran-2-one moiety in the side chain. Compounds 1-5 and 9 have a 3,19-hemiketal bridge in the A ring. In an in vivo bioassay, 1, 2, and 4-6 exhibited significant preventive effects on zebrafish heart failure at 0.5 mu g/mL, improving heart dilatation, venous congestion, cardiac output, blood flow velocity, and heart rate. Compound 5, displaying the most promising heart failure preventive activities, showed even better effects on increasing cardiac output (72%) and blood flow velocity (83%) than six first-line heart failure therapeutic drugs. Moreover, 1, 2, and 6 prevented the formation of thrombosis in zebrafish at 0.5 mu g/mL. The present investigation suggests that the new dammarane triterpenoids might be partially responsible for the utility of R. chinensis in treating coronary artery heart disease.
WOS关键词CHEMICAL-CONSTITUENTS ; NATURAL-PRODUCTS ; MODEL
资助项目National Natural Science Foundation of China[81803678] ; National Natural Science Foundation of China[81872990] ; Projects of Fujian Provincial Health Commission[2017-ZQN-65] ; Fujian Provincial Department of Education[JT180252] ; School Supervision Subject of Fujian University of Traditional Chinese Medicine[X2019002] ; Youth Innovation Promotion Association from Chinese Academy of Sciences[2016258] ; SA-SIBS Scholarship Program
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000517856600021
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/281389]  
专题新药研究国家重点实验室
通讯作者Xu, Wei; Li, Xu-Wen
作者单位1.Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou 350122, Peoples R China
2.Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, Fuzhou 350122, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Ye, Miao,Xu, Wen,He, Qing,et al. Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(2):362-373.
APA Ye, Miao.,Xu, Wen.,He, Qing.,Wu, Xian.,Lai, Wen-Fang.,...&Li, Xu-Wen.(2020).Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis.JOURNAL OF NATURAL PRODUCTS,83(2),362-373.
MLA Ye, Miao,et al."Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis".JOURNAL OF NATURAL PRODUCTS 83.2(2020):362-373.

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来源：上海药物研究所

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