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A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis

文献类型：期刊论文

作者Ouyang, Xumei1,2,3,4; Wang, Xiaoling1,2,3; Kraatz, Heinz-Bernhard5; Ahmadi, Soha5; Gao, Jianqing2,3; Lv, Yuanyuan1; Sun, Xiaoyi1; Huang, Yongzhuo6
刊名BIOMATERIALS SCIENCE
出版日期2020-02-21
卷号8期号:4页码:1160-1170
ISSN号2047-4830
DOI10.1039/c9bm01401b
通讯作者Sun, Xiaoyi(sunxiaoyi@zucc.edu.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Mesenchymal stem cell (MSC)-based biomimetic delivery has been actively explored for drug accumulation and penetration into tumors by taking advantage of the tumor-tropic and penetration properties of MSCs. In this work, we further demonstrated the feasibility of MSC-mediated nano drug delivery, which was characterized by the "Trojan horse"-like transport via an endocytosis-exocytosis-endocytosis process between MSCs and cancer cells. Chlorin e6 (Ce6)-conjugated polydopamine nanoparticles (PDA-Ce6) were developed and loaded into the MSCs. Phototherapeutic agents are safe to the MSCs, and their very low dark toxicity causes no impairment of the inherent properties of MSCs, including tumor-homing ability. The MSCs loaded with PDA-Ce6 (MSC-PDA-Ce6) were able to target and penetrate into tumors and exocytose 60% of the payloads in 72 h. The released PDA-Ce6 NPs could penetrate deep and be re-endocytosed by the cancer cells. MSC-PDA-Ce6 tended to accumulate in the lungs and delivered PDA-Ce6 into the tumors after intravenous injection in the mouse model with lung melanoma metastasis. Phototoxicity can be selectively triggered in the tumors by sequentially treating with near-infrared irradiation to induce photodynamic therapy (PDT) and photothermal therapy (PTT). The MSC-based biomimetic delivery of PDA-Ce6 nanoparticles is a potential method for dual phototherapy against lung melanoma metastasis.
WOS关键词LOADED NANOPARTICLES ; PHOTOTHERMAL THERAPY ; CELLULAR UPTAKE ; GENE DELIVERY ; CANCER ; EXOCYTOSIS ; NANOCARRIERS ; ENHANCEMENT ; PENETRATION ; VEHICLE
资助项目National Natural Science Foundation of China[81925035] ; National Natural Science Foundation of China[81402872] ; National Natural Science Foundation of China[81620108028] ; Natural Science Foundation of Zhejiang Province[LY17H160002] ; Natural Science Foundation of Zhejiang Province[LY17B020002] ; Agricultural and Social Development Program of Hangzhou[20191203B48]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000517148800011
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/281403]  
专题新药研究国家重点实验室
通讯作者Sun, Xiaoyi; Huang, Yongzhuo
作者单位1.Zhejiang Univ City Coll, Dept Pharm, Hangzhou 310015, Peoples R China
2.Wenzhou Med Univ, Sch Ophthalmol & Optometry, Dept Pharm, Wenzhou 325035, Peoples R China
3.Wenzhou Med Univ, Eye Hosp, Wenzhou 325035, Peoples R China
4.Zhejiang Univ, Coll Pharmaceut Sci, Dept Pharmaceut, Hangzhou 310058, Peoples R China
5.Univ Toronto, Dept Phys & Environm Sci, Scarborough, ON M1C 1A4, Canada
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Ouyang, Xumei,Wang, Xiaoling,Kraatz, Heinz-Bernhard,et al. A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis[J]. BIOMATERIALS SCIENCE,2020,8(4):1160-1170.
APA Ouyang, Xumei.,Wang, Xiaoling.,Kraatz, Heinz-Bernhard.,Ahmadi, Soha.,Gao, Jianqing.,...&Huang, Yongzhuo.(2020).A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis.BIOMATERIALS SCIENCE,8(4),1160-1170.
MLA Ouyang, Xumei,et al."A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis".BIOMATERIALS SCIENCE 8.4(2020):1160-1170.

入库方式： OAI收割

来源：上海药物研究所

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