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Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy

文献类型：期刊论文

作者Wang, Hong1,2,5; Li, Jie1,2,5; Wang, Yuqi1,2; Gong, Xiang1,2,5; Xu, Xiaoxuan1,2,5; Wang, Jiaoying1,2; Li, Yaping1,2,4; Sha, Xianyi6; Zhang, Zhiwen1,2,3
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2020-03-10
卷号319页码:25-45
ISSN号0168-3659
关键词Tumor hypoxia Nanoparticles Oxygen Cancer therapy
DOI10.1016/j.jconrel.2019.12.028
通讯作者Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zwzhang0125@simm.ac.cn)
英文摘要Tumor hypoxia is a characteristic hallmark of malignant solid tumors, which remains an essential impediment to many current treatments like chemotherapy, radiotherapy, photodynamic therapy and immunotherapy, thereby leading to poor clinical prognosis after therapy. Rationally, modulating tumor hypoxia can be of great interest to augment the therapeutic efficacy of these treatments. In this review, we focus our discussion on current advances in nanoparticles-mediated tumor reoxygenation strategy for relieving tumor hypoxia to improve the therapeutic efficacy of versatile therapies. These nanoparticles can improve tumor oxygen levels via nanoparticles-mediated oxygen-carrying or oxygen-generating tactics to synergize the effectiveness of many current therapeutic modalities. Based on these considerable summaries and analyses, we propose some feasible perspectives on nanoparticles-based tumor reoxygenations to ameliorate the therapeutic outcomes.
WOS关键词PHOTODYNAMIC THERAPY ; BLOOD SUBSTITUTES ; OXYGEN ; RADIOTHERAPY ; DELIVERY ; MICROENVIRONMENT ; CHEMOTHERAPY ; METASTASIS ; RESISTANCE ; HEMOGLOBIN
资助项目Strategic Priority Research Program of CAS[XDA12050307] ; National Natural Science Foundation of China[31771092] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2012223] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000515538300003
源URL[http://119.78.100.183/handle/2S10ELR8/281408]  
专题新药研究国家重点实验室
通讯作者Li, Yaping; Zhang, Zhiwen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Shandong 264000, Peoples R China
4.Yantai Univ, Sch Pharm, Shandong 264000, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Hong,Li, Jie,Wang, Yuqi,et al. Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,319:25-45.
APA Wang, Hong.,Li, Jie.,Wang, Yuqi.,Gong, Xiang.,Xu, Xiaoxuan.,...&Zhang, Zhiwen.(2020).Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy.JOURNAL OF CONTROLLED RELEASE,319,25-45.
MLA Wang, Hong,et al."Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy".JOURNAL OF CONTROLLED RELEASE 319(2020):25-45.

入库方式： OAI收割

来源：上海药物研究所

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