Supramolecular Prodrug Nanovectors for Active Tumor Targeting and Combination Immunotherapy of Colorectal Cancer
文献类型：期刊论文
| 作者 | Hu, Xianli1,2,3; Hou, Bo1,2,3; Xu, Zhiai1; Saeed, Madiha2,3; Sun, Fang2,3; Gao, Zhenmei1; Lai, Yi1; Zhu, Tong1; Zhang, Fan4; Zhang, Wen1 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2020-02-25 |
| 页码 | 14 |
| 关键词 | active tumor targeting cancer management colorectal cancer combination immunotherapy photodynamic immunotherapy prodrugs supramolecular nanovectors |
| DOI | 10.1002/advs.201903332 |
| 通讯作者 | Yu, Haijun(hjyu@simm.ac.cn) |
| 英文摘要 | Immunotherapy aiming to harness the exquisite power of the immune system has emerged as a crucial part of clinical cancer management. However, only a subset of cancer patients responds to current immunotherapy because of low immunogenicity of the tumor cells and immunosuppressive tumor microenvironment. Herein, host-guest prodrug nanovectors are reported for active tumor targeting and combating immune tolerance in tumors. The prodrug nanovectors are designed by integrating hyaluronic acid (HA) and reduction-labile heterodimer of Pheophorbide A (PPa) and NLG919 into the supramolecular nanocomplexes, where PPa and NLG919 act as a photosensitizer and potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), respectively. Meanwhile, HA is employed to achieve active tumor targeting by recognizing CD44 overexpressed on the surface of tumor cell membranes. Near infrared (NIR) laser irradiation triggers the release of reactive oxygen species to provoke antitumor immunogenicity and intratumoral infiltration of cytotoxic T lymphocytes (CTLs). Meanwhile, the immunosuppressive tumor microenvironment (ITM) is reversed by NLG919-mediated IDO-1 inhibition. Combination of photodynamic immunotherapy and IDO-1 blockade efficiently eradicates CT26 colorectal tumors in the immunocompetent mice. The host-guest nanoplatform capable of eliciting effective antitumor immunity by inactivating inhibitory immune response can be applied to other immune modulators for improved cancer immunotherapy. |
| WOS关键词 | HYALURONIC-ACID ; IMMUNE ; NANOPARTICLES ; PD-1/PD-L1 ; BLOCKADE ; INHIBITORS ; DELIVERY ; DRUG |
| 资助项目 | National Natural Science Foundation of China[21675055] ; National Natural Science Foundation of China[21775046] ; National Natural Science Foundation of China[21635003] ; National Natural Science Foundation of China[31622025] ; Youth Innovation Promotion. Association of Chinese Academy of Sciences[2014218] ; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences[2019-027] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000515711300001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281416]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun |
| 作者单位 | 1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Fudan Univ, Dept Chem, Shanghai 200438, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xianli,Hou, Bo,Xu, Zhiai,et al. Supramolecular Prodrug Nanovectors for Active Tumor Targeting and Combination Immunotherapy of Colorectal Cancer[J]. ADVANCED SCIENCE,2020:14. |
| APA | Hu, Xianli.,Hou, Bo.,Xu, Zhiai.,Saeed, Madiha.,Sun, Fang.,...&Yu, Haijun.(2020).Supramolecular Prodrug Nanovectors for Active Tumor Targeting and Combination Immunotherapy of Colorectal Cancer.ADVANCED SCIENCE,14. |
| MLA | Hu, Xianli,et al."Supramolecular Prodrug Nanovectors for Active Tumor Targeting and Combination Immunotherapy of Colorectal Cancer".ADVANCED SCIENCE (2020):14. |
入库方式： OAI收割
来源：上海药物研究所
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