Allostery in Drug Development
文献类型：期刊论文
| 作者 | Cheng, Xi; Jiang, Hualiang
|
| 刊名 | PROTEIN ALLOSTERY IN DRUG DISCOVERY
 |
| 出版日期 | 2019 |
| 卷号 | 1163页码:1-23 |
| 关键词 | Allosteric perturbation Biased agonists Conformational changes Protein dynamics Rational drug design |
| ISSN号 | 0065-2598 |
| DOI | 10.1007/978-981-13-8719-7_1 |
| 通讯作者 | Jiang, Hualiang(hljiang@simm.ac.cn) |
| 英文摘要 | Allosteric regulation is a ubiquitous strategy employed in nature to control cellular processes by regulating the affinities of biomolecules. Allosteric modulators are able to tune the protein/substrate affinity in a highly predictable way, suggesting that such modulators may represent safe drugs. Tremendous advances have been made in the development of allosteric modulators and the characterization of their therapeutic targets. Here, we briefly introduce several representative allosteric modulators of important drug targets, such as the G protein-coupled receptor family. We also review the state-of-the-art experimental and computational approaches used in allosteric drug development. The accumulated knowledge of allosteric regulation and the technical progress made in drug development will lead to an explosion of promising allosteric drugs in the near future. |
| WOS关键词 | MARKOV STATE MODELS ; MU-OPIOID RECEPTOR ; LIGAND-BINDING SITES ; DRUGGABLE HOT-SPOTS ; BETA-ARRESTIN ; SMALL-MOLECULE ; DISORDERED PROTEIN ; BIASED AGONISM ; DOUBLE-BLIND ; GPCR |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000514080400002 |
| 出版者 | SPRINGER INTERNATIONAL PUBLISHING AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281419]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Jiang, Hualiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Xi,Jiang, Hualiang. Allostery in Drug Development[J]. PROTEIN ALLOSTERY IN DRUG DISCOVERY,2019,1163:1-23. |
| APA | Cheng, Xi,&Jiang, Hualiang.(2019).Allostery in Drug Development.PROTEIN ALLOSTERY IN DRUG DISCOVERY,1163,1-23. |
| MLA | Cheng, Xi,et al."Allostery in Drug Development".PROTEIN ALLOSTERY IN DRUG DISCOVERY 1163(2019):1-23. |
入库方式： OAI收割
来源：上海药物研究所
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