Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury
文献类型：期刊论文
| 作者 | Wu, Shou-yan1,2; Wang, Wen-jie1,2; Dou, Jin-hui3; Gong, Li-kun1,2
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2020-03-06 |
| 页码 | 9 |
| 关键词 | 18 beta-glycyrrhetic acid licorice preparation liver injury glycyrrhetinic acid target |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-020-0383-9 |
| 通讯作者 | Gong, Li-kun(lkgong@cdser.simm.ac.cn) |
| 英文摘要 | The first description of the medical use of licorice appeared in "Shennong Bencao Jing", one of the well-known Chinese herbal medicine classic books dated back to 220-280 AD. As one of the most commonly prescribed Chinese herbal medicine, licorice is known as "Guo Lao", meaning "a national treasure" in China. Modern pharmacological investigations have confirmed that licorice possesses a number of biological activities, such as antioxidation, anti-inflammatory, antiviral, immune regulation, and liver protection. 18 beta-glycyrrhetinic acid is one of the most extensively studied active integrants of licorice. Here, we provide an overview of the protective effects of 18 beta-glycyrrhetinic acid against various acute and chronic liver diseases observed in experimental models, and summarize its pharmacological effects and potential toxic/side effects at higher doses. We also make additional comments on the important areas that may warrant further research to support appropriate clinical applications of 18 beta-glycyrrhetinic acid and avoid potential risks. |
| WOS关键词 | ALPHA-NAPHTHYL ISOTHIOCYANATE ; HEPATIC STELLATE CELLS ; NF-KAPPA-B ; GLYCYRRHETINIC ACID ; GLYCYRRHIZIC ACID ; IN-VITRO ; INDUCED HEPATOTOXICITY ; DOWN-REGULATION ; APOPTOSIS ; RATS |
| 资助项目 | National New Drug Creation Program of China[2018ZX09201017-004] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050305] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000518308100001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281436]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Gong, Li-kun |
| 作者单位 | 1.Chinese Acad Sci, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Oxford, MS 38677 USA |
| 推荐引用方式 GB/T 7714 | Wu, Shou-yan,Wang, Wen-jie,Dou, Jin-hui,et al. Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury[J]. ACTA PHARMACOLOGICA SINICA,2020:9. |
| APA | Wu, Shou-yan,Wang, Wen-jie,Dou, Jin-hui,&Gong, Li-kun.(2020).Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury.ACTA PHARMACOLOGICA SINICA,9. |
| MLA | Wu, Shou-yan,et al."Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury".ACTA PHARMACOLOGICA SINICA (2020):9. |
入库方式： OAI收割
来源：上海药物研究所
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