Roles of Renal Drug Transporter in Drug Disposition and Renal Toxicity
文献类型：期刊论文
| 作者 | Yang, Xinning1; Han, Li2 |
| 刊名 | DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY
 |
| 出版日期 | 2019 |
| 卷号 | 1141页码:341-360 |
| ISSN号 | 0065-2598 |
| 关键词 | SLC transporters ABC transporters Drug disposition Nephrotoxicity |
| DOI | 10.1007/978-981-13-7647-4_7 |
| 通讯作者 | Yang, Xinning(xinning.yang@fda.hhs.gov) |
| 英文摘要 | The kidney plays an important role in maintaining total body homeostasis and eliminating toxic xenobiotics and metabolites. Numerous drugs and their metabolites are ultimately eliminated in the urine. The reabsorption and secretion functions of the nephron are mediated by a variety of transporters located in the basolateral and luminal membranes of the tubular cells. In the past decade, many studies indicated that transporters play important roles in drug pharmacokinetics and demonstrated the impact of renal transporters on the disposition of drugs, drug-drug interactions, and nephrotoxicities. Here, we focus on several important renal transporters and their roles in drug elimination and disposition, drug-induced nephrotoxicities and potential clinical solutions. |
| WOS关键词 | BREAST-CANCER RESISTANCE ; ORGANIC ANION TRANSPORTERS ; TENOFOVIR DISOPROXIL FUMARATE ; BALKAN ENDEMIC NEPHROPATHY ; HIGH-DOSE METHOTREXATE ; ARISTOLOCHIC ACID ; DIGOXIN CLEARANCE ; TUBULAR SECRETION ; IN-VITRO ; FUNCTIONAL-CHARACTERIZATION |
| WOS研究方向 | Cell Biology ; Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | SPRINGER INTERNATIONAL PUBLISHING AG |
| WOS记录号 | WOS:000514283700008 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281439]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yang, Xinning |
| 作者单位 | 1.US FDA, Off Clin Pharmacol, Off Translat Sci, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xinning,Han, Li. Roles of Renal Drug Transporter in Drug Disposition and Renal Toxicity[J]. DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY,2019,1141:341-360. |
| APA | Yang, Xinning,&Han, Li.(2019).Roles of Renal Drug Transporter in Drug Disposition and Renal Toxicity.DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY,1141,341-360. |
| MLA | Yang, Xinning,et al."Roles of Renal Drug Transporter in Drug Disposition and Renal Toxicity".DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY 1141(2019):341-360. |
入库方式： OAI收割
来源：上海药物研究所
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