中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents

文献类型：期刊论文

作者Lin, Ying1; Xing, Dong1; Wu, Wen-Biao2,3; Xu, Gao-Ya2,3; Yu, Li-Fang1; Tang, Jie1,4; Zhou, Yu-Bo2,3; Li, Jia2,3,5; Yang, Fan1
刊名MOLECULES
出版日期2020
卷号25期号:1页码:13
关键词benzofuro[3,2-c]quinolines 3-(2-methoxyphenyl)quinolin-4(1H)one MV-4-11 cell line antileukemia activity
DOI10.3390/molecules25010203
通讯作者Li, Jia(jli@simm.ac.cn) ; Yang, Fan(fyang@chem.ecnu.edu.cn)
英文摘要Herein, we design and synthesize an array of benzofuro[3,2-c]quinolines starting from 3-(2-methoxyphenyl)quinolin-4(1H)ones via a sequential chlorination/demethylation, intramolecular cyclization pathway. This sequential transformation was efficient, conducted under metal-free and mild reaction conditions, and yielded corresponding benzofuro[3,2-c]quinolines in high yields. In vitro biological evaluation indicated that such type of compounds showed excellent antileukemia activity and selectivity, and therefore may offer a promising hit compound for developing antileukemia compounds.
WOS关键词INHIBITORS ; DISCOVERY ; BENZOFUROQUINOLINES ; IDENTIFICATION ; CYCLIZATION ; ARYLATION ; DRUG
资助项目national Natural Science Foundation of China[21772043]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000513770000203
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/281443]  
专题中国科学院上海药物研究所
通讯作者Li, Jia; Yang, Fan
作者单位1.East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China
2.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Shanghai Greenchem & Biotech Co Ltd, Shanghai 200062, Peoples R China
5.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Lin, Ying,Xing, Dong,Wu, Wen-Biao,et al. Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents[J]. MOLECULES,2020,25(1):13.
APA Lin, Ying.,Xing, Dong.,Wu, Wen-Biao.,Xu, Gao-Ya.,Yu, Li-Fang.,...&Yang, Fan.(2020).Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents.MOLECULES,25(1),13.
MLA Lin, Ying,et al."Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents".MOLECULES 25.1(2020):13.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。