Recent advances in dopaminergic strategies for the treatment of Parkinson's disease
文献类型：期刊论文
| 作者 | Mao, Qi1,2; Qin, Wang-zhi1,2; Zhang, Ao3,4,5 ; Ye, Na1,2
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2020-02-28 |
| 页码 | 12 |
| 关键词 | Parkinson's disease dopamine D-1 receptor D-2 receptor allosteric modulator neuroprotection multitarget drug discovery and development neurodegenerative diseases |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-020-0365-y |
| 通讯作者 | Ye, Na(yena@suda.edu.cn) |
| 英文摘要 | Parkinson's disease (PD) is the second most common progressive neurodegenerative disease worldwide. However, there is no available therapy reversing the neurodegenerative process of PD. Based on the loss of dopamine or dopaminergic dysfunction in PD patients, most of the current therapies focus on symptomatic relief to improve patient quality of life. As dopamine replacement treatment remains the most effective symptomatic pharmacotherapy for PD, herein we provide an overview of the current pharmacotherapies, summarize the clinical development status of novel dopaminergic agents, and highlight the challenge and opportunity of emerging preclinical dopaminergic approaches aimed at managing the features and progression of PD. |
| WOS关键词 | METABOTROPIC GLUTAMATE RECEPTORS ; MONOAMINE-OXIDASE INHIBITION ; LEVODOPA-INDUCED DYSKINESIA ; SUBTYPE-SELECTIVE AGENTS ; IN-VIVO CHARACTERIZATION ; 5-HT1A DUAL-AGONIST ; MAO-B INHIBITORS ; ALLOSTERIC MODULATORS ; D2/D3 AGONIST ; NONDOPAMINERGIC TREATMENTS |
| 资助项目 | National Natural Science Foundation of China[81703330] ; Natural Science Foundation of Jiangsu Province[BK20170347] ; Priority Academic Program Development of the Jiangsu Higher Education Institutes (PAPD) ; Jiangsu Key Laboratory of Neuropsychiatric Diseases[BM2013003] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000517048200003 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281449]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ye, Na |
| 作者单位 | 1.Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Peoples R China 2.Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China 3.Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Qi,Qin, Wang-zhi,Zhang, Ao,et al. Recent advances in dopaminergic strategies for the treatment of Parkinson's disease[J]. ACTA PHARMACOLOGICA SINICA,2020:12. |
| APA | Mao, Qi,Qin, Wang-zhi,Zhang, Ao,&Ye, Na.(2020).Recent advances in dopaminergic strategies for the treatment of Parkinson's disease.ACTA PHARMACOLOGICA SINICA,12. |
| MLA | Mao, Qi,et al."Recent advances in dopaminergic strategies for the treatment of Parkinson's disease".ACTA PHARMACOLOGICA SINICA (2020):12. |
入库方式： OAI收割
来源：上海药物研究所
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