Synthesis and Cdc25B/PTP1B Inhibitory Activity Evaluation of Novel Carbazole-Based Mono-/Bis-thiocarbohydrazone Derivatives
文献类型：期刊论文
| 作者 | Li Yingjun1; Yang Kaidong1; Jin Kun2; Gao Lixin3; Sheng Li3; Liu Xuejie1; Yang Hongjing1; Lin Ledi1; Li Jia3
|
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2020-01-25 |
| 卷号 | 40期号:1页码:162-174 |
| 关键词 | thiocarbohydrazone carbazole synthesis Cdc25B and PTP1B inhibitor molecular docking DFT calculations |
| ISSN号 | 0253-2786 |
| DOI | 10.6023/cjoc201905043 |
| 通讯作者 | Li Yingjun(chemlab.lnnu@163.com) ; Li Jia(jli@simm.ac.cn) |
| 英文摘要 | A series of novel carbazole-based mono-/bis-thiocarbohydrazone derivatives were synthesized. Their structures were characterized by IR, H-1 NMR, C-13 NMR spectra and elemental analysis. The inhibitory activities of the target compounds against Cdc25B/PTP1B were evaluated, and the relationship between structure and activity was discussed. The results showed that most of the target compounds had good inhibitory activity against Cdc25B and PTP1B. Among them, 1,5-bis[(9-pentyl-3-carbazolyl)methylene]thiocarbohydrazone (4d) had the highest inhibitory activity against Cdc25B with IC50=(0.23 +/- 0.02) mu g/mL, and 1,5-bis[(9-ethyl-3-carbazolyl)methylene]thiocarbohydrazone (4a) had the highest inhibitory activity against PTP1B with IC50=(1.00 +/- 0.16) mu g/mL. Molecular docking and density functional theory (DFT) calculations of the target compounds 4a and 4d were performed. Molecular docking results indicated that the target compounds 4d and 4a entered the active sites of Cdc25B and PTP1B enzymes, respectively, and thiocarbohydrazone and carbazole groups play the importent role of activity. |
| WOS关键词 | BIOLOGICAL EVALUATION ; IN-VITRO ; AMINOALCOHOLS ; ANTICANCER ; RECEPTOR ; AMIDES ; IONS |
| 资助项目 | Natural Science Foundation of Liaoning Province[20102126] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000518131500018 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281467]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li Yingjun; Li Jia |
| 作者单位 | 1.Liaoning Normal Univ, Coll Chem & Chem Engn, Dalian 116029, Liaoning, Peoples R China 2.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Liaoning, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Yingjun,Yang Kaidong,Jin Kun,et al. Synthesis and Cdc25B/PTP1B Inhibitory Activity Evaluation of Novel Carbazole-Based Mono-/Bis-thiocarbohydrazone Derivatives[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2020,40(1):162-174. |
| APA | Li Yingjun.,Yang Kaidong.,Jin Kun.,Gao Lixin.,Sheng Li.,...&Li Jia.(2020).Synthesis and Cdc25B/PTP1B Inhibitory Activity Evaluation of Novel Carbazole-Based Mono-/Bis-thiocarbohydrazone Derivatives.CHINESE JOURNAL OF ORGANIC CHEMISTRY,40(1),162-174. |
| MLA | Li Yingjun,et al."Synthesis and Cdc25B/PTP1B Inhibitory Activity Evaluation of Novel Carbazole-Based Mono-/Bis-thiocarbohydrazone Derivatives".CHINESE JOURNAL OF ORGANIC CHEMISTRY 40.1(2020):162-174. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。