Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model
文献类型：期刊论文
| 作者 | Chi, Liandi1; Khan, Imran2; Lin, Zibei1; Zhang, Jiwen3,4 ; Lee, M. Y. Simon1; Leong, Waikit2; Hsiao, W. L. Wendy2; Zheng, Ying1
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| 刊名 | PHYTOMEDICINE
 |
| 出版日期 | 2020-02-01 |
| 卷号 | 67页码:12 |
| ISSN号 | 0944-7113 |
| 关键词 | Inulin-type fructo-oligosaccharides (FOSs) Chronic unpredictable mild stress (CUMS) Behavioral tests Gut microbiota |
| DOI | 10.1016/j.phymed.2019.153157 |
| 通讯作者 | Hsiao, W. L. Wendy(wlhsiao@must.edu.mo) ; Zheng, Ying(yzheng@um.edu.mo) |
| 英文摘要 | Background: Inulin-type fructo-oligosaccharides (FOSs) purified from Morinda officinalis How., an effective oral antidepressant for mild to moderate depression, have a largely unknown efficacy and poor bioavailability. Purpose: Therefore, the microbiota-gut-brain axis was used to investigate the antidepressive properties of FOSs at the interface of the gut microbiota (GM). Study design and methods: FOSs was introduced via intragastric gavage to rats exposed to chronic unpredictable mild stress (CUMS), and the antidepressive effects were investigated through behavioral tests, intestinal morphology and corticosterone levels. Bacterial genomic DNA was extracted from feces, and the GM was profiled for using enterobacterial repetitive intergenic consensus (ERIC) PCR analysis, partial least squares-discriminant analysis (PLS-DA) and 16S rRNA gene pyrosequencing. Results: It was observed that FOSs alleviated depression-like behaviors and repaired intestinal epithelia damages. FOSs treatment lowered corticosterone levels in the plasma and urine of the model rats. Moreover, the GM compositions of normal and model rats were distantly clustered and were mainly related to the disappearance of beneficial bacteria (e.g., Acinetobacter, Barnesiella, Coprococcus, Dialister, Lactobacillus, and Paenibacillus) and appearance of depression-associated bacteria (e.g., Anaerostipes, Oscillibacter, Proteobacteria, and Streptococcus) in depressive rats. Interestingly, the dysbiosis in depressive rats' gut was reinstated with FOSs treatments. Notably, FOSs promoted the abundance of the bacterial phylum Cyanobacteria, a group of bacteria known for the secretion of pharmacologically important metabolites, such as H2S, that exhibit antidepressantlike properties. Apparently, FOSs-induced modulation of GM was more antidepressive compared to a component of FOSs, degrees of polymerization (DP) 5, and fluoxetine, the standard antidepressant drug. Conclusion: In conclusion, this study implied that antidepressant efficacy of FOSs was inseparable from and strongly associated with the modulation of the host' s GM. |
| WOS关键词 | FECAL MICROBIOTA ; LACTOBACILLUS ; ANXIETY ; MILD |
| 资助项目 | University of Macau[MYRG2016-00090-ICMS-QRCM] ; Macau[FDCT [103/2016/A3]] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| 出版者 | ELSEVIER GMBH |
| WOS记录号 | WOS:000517517600009 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281472]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hsiao, W. L. Wendy; Zheng, Ying |
| 作者单位 | 1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China 2.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China 3.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chi, Liandi,Khan, Imran,Lin, Zibei,et al. Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model[J]. PHYTOMEDICINE,2020,67:12. |
| APA | Chi, Liandi.,Khan, Imran.,Lin, Zibei.,Zhang, Jiwen.,Lee, M. Y. Simon.,...&Zheng, Ying.(2020).Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model.PHYTOMEDICINE,67,12. |
| MLA | Chi, Liandi,et al."Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model".PHYTOMEDICINE 67(2020):12. |
入库方式： OAI收割
来源：上海药物研究所
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