中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Molecular Imaging for Cancer Immunotherapy: Seeing Is Believing

文献类型：期刊论文

作者Saeed, Madiha1,2; Xu, Zhiai3; De Geest, Bruno G.4,5; Xu, Huixiong6; Yu, Haijun1,2
刊名BIOCONJUGATE CHEMISTRY
出版日期2020-02-01
卷号31期号:2页码:404-415
ISSN号1043-1802
DOI10.1021/acs.bioconjchem.9b00851
通讯作者Yu, Haijun(hjyu@simm.ac.cn)
英文摘要The importance of the immune system in cancer therapy has been reaffirmed by the success of the immune checkpoint blockade. The complex tumor microenvironment and its interaction with the immune system, however, remain mysteries. Molecular imaging may shed light on fundamental aspects of the immune response to elucidate the mechanism of cancer immunotherapy. In this review, we discuss various imaging approaches that offer in-depth insight into the tumor microenvironment, checkpoint blockade therapy, and T cell-mediated antitumor immune responses. Recent advances in the molecular imaging modalities, including magnetic resonance imaging (MRI), positron electron tomography (PET), and optical imaging (e.g., fluorescence and intravital imaging) for in situ tracking of the immune response, are discussed. It is envisaged that the integration of imaging with immunotherapy may broaden our understanding to predict a particular antitumor immune response.
WOS关键词IMMUNE CHECKPOINT BLOCKADE ; T-CELLS ; IN-VIVO ; DENDRITIC CELLS ; ANTIBODY ; NANOPARTICLES ; PET ; ANTI-PD-1 ; TRACKING ; GLIOBLASTOMA
资助项目National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[81671695] ; National Natural Science Foundation of China[81725008] ; CAS President's International Fellowship Initiative Program[2019PB0023] ; Shanghai Municipal Health Commission[2019LJ21] ; Science and Technology Commission of Shanghai Municipality[19441903200] ; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences[2019-027]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000515196200023
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/281498]  
专题新药研究国家重点实验室
通讯作者Yu, Haijun
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China
4.Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium
5.Univ Ghent, CRIG, B-9000 Ghent, Belgium
6.Tongji Univ, Shanghai Peoples Hosp 10, Ultrasound Res & Educ Inst, Sch Med,Canc Ctr,Dept Med Ultrasound, Shanghai 200072, Peoples R China
推荐引用方式
GB/T 7714		 Saeed, Madiha,Xu, Zhiai,De Geest, Bruno G.,et al. Molecular Imaging for Cancer Immunotherapy: Seeing Is Believing[J]. BIOCONJUGATE CHEMISTRY,2020,31(2):404-415.
APA Saeed, Madiha,Xu, Zhiai,De Geest, Bruno G.,Xu, Huixiong,&Yu, Haijun.(2020).Molecular Imaging for Cancer Immunotherapy: Seeing Is Believing.BIOCONJUGATE CHEMISTRY,31(2),404-415.
MLA Saeed, Madiha,et al."Molecular Imaging for Cancer Immunotherapy: Seeing Is Believing".BIOCONJUGATE CHEMISTRY 31.2(2020):404-415.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。