Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy
文献类型：期刊论文
| 作者 | Guo, Shi-yan1,2,3; Sun, Di1,2; Ni, Da-long4; Yu, Miao-rong3; Qian, Kun3; Zhang, Wei3; Yang, Yi-wei3; Song, Sha3; Li, Yang1,2; Xi, Zi-yue3 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2020-02-28 |
| 页码 | 11 |
| 关键词 | hypoxia relief mesoporous calcium silicate sequential functions sustained drug release synergetic effects |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.202000486 |
| 通讯作者 | Chen, Kai-xian(kxchen@simm.ac.cn) ; Gan, Yong(ygan@simm.ac.cn) ; Wang, Zheng-tao(ztwang@shutcm.edu.cn) |
| 英文摘要 | The tumor microenvironment (TME), which includes acidic and hypoxic conditions, severely impedes the therapeutic efficacy of antitumor agents. Herein, MnO2-loaded, bovine serum albumin, and PEG co-modified mesoporous CaSiO3 nanoparticles (CaM-PB NPs) are developed as a nanoplatform with sequential theranostic functions for the engineering of TME. The MnO2 NPs generate O-2 in situ by reacting with endogenous H2O2, relieving the hypoxic state of the TME that further modulates the cancer cell cycle status to S phase, which improves the potency of co-loaded S phase-sensitive chemotherapeutic drugs. After the hypoxia relief, CaM-PB can sustainably release drugs due to the enlarged pores of mesoporous CaSiO3 in the acidic TME, preventing the drug pre-leakage into the blood circulation and insufficient drug accumulation at tumor sites. Moreover, the Mn2+ released from the MnO2 NPs at tumor sites can potentially serve as a diagnostic agent, enabling the identification of tumor regions by T-1-weighted magnetic resonance imaging during therapy. In vivo pharmacodynamics results demonstrate that these synergetic effects caused by CaM-PB NPs significantly contribute to the inhibition of tumor progression. Therefore, the CaM-PB NPs with sequential theranostic functions are a promising system for effective cancer therapy. |
| WOS关键词 | BOVINE SERUM-ALBUMIN ; DRUG-DELIVERY ; CELLULAR UPTAKE ; MAGNETIC NANOPARTICLES ; CIRCULATION TIME ; CALCIUM SILICATE ; HYPOXIA ; MRI ; 10-HYDROXYCAMPTOTHECIN ; ANGIOGENESIS |
| 资助项目 | National Natural Science Foundation of China[81773651] ; National Natural Science Foundation of China[81573378] ; National Natural Science Foundation of China[81803445] ; National Natural Science Foundation of China[81920108033] ; National Natural Science Foundation of China[81703010] ; National Natural Science Foundation of China[81872428] ; Shanghai Scientific and Technology Innovation Plan ; Shanghai Science and Technology Committee[18430721600] ; China Postdoctoral Science Foundation[2016M600342] ; New Star Program, Shanghai Institute of Materia Medica, CAS ; CAS Key Technology Talent Program |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000516838600001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281507]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Kai-xian; Gan, Yong; Wang, Zheng-tao |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, MOE Key Lab Standardizat Chinese Med, 1200 Cailun Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai Key Lab Compound Chinese Med, 1200 Cailun Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA |
| 推荐引用方式 GB/T 7714 | Guo, Shi-yan,Sun, Di,Ni, Da-long,et al. Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2020:11. |
| APA | Guo, Shi-yan.,Sun, Di.,Ni, Da-long.,Yu, Miao-rong.,Qian, Kun.,...&Wang, Zheng-tao.(2020).Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,11. |
| MLA | Guo, Shi-yan,et al."Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS (2020):11. |
入库方式： OAI收割
来源：上海药物研究所
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